Towards Explainable Graph Representations in Digital Pathology

• URL: http://arxiv.org/abs/2007.00311v1
• Date: Wed, 1 Jul 2020 08:05:26 GMT
• Title: Towards Explainable Graph Representations in Digital Pathology
• Authors: Guillaume Jaume, Pushpak Pati, Antonio Foncubierta-Rodriguez, Florinda Feroce, Giosue Scognamiglio, Anna Maria Anniciello, Jean-Philippe Thiran, Orcun Goksel, Maria Gabrani
• Abstract summary: We introduce a post-hoc explainer to derive compact per-instance explanations emphasizing diagnostically important entities in the graph. Although we focus our analyses to cells and cellular interactions in breast cancer subtyping, the proposed explainer is generic enough to be extended to other topological representations in digital pathology.
• Score: 9.369422379741982
• License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
• Abstract: Explainability of machine learning (ML) techniques in digital pathology (DP) is of great significance to facilitate their wide adoption in clinics. Recently, graph techniques encoding relevant biological entities have been employed to represent and assess DP images. Such paradigm shift from pixel-wise to entity-wise analysis provides more control over concept representation. In this paper, we introduce a post-hoc explainer to derive compact per-instance explanations emphasizing diagnostically important entities in the graph. Although we focus our analyses to cells and cellular interactions in breast cancer subtyping, the proposed explainer is generic enough to be extended to other topological representations in DP. Qualitative and quantitative analyses demonstrate the efficacy of the explainer in generating comprehensive and compact explanations.

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