Relation-weighted Link Prediction for Disease Gene Identification

• URL: http://arxiv.org/abs/2011.05138v3
• Date: Fri, 13 Nov 2020 14:48:00 GMT
• Title: Relation-weighted Link Prediction for Disease Gene Identification
• Authors: Srivamshi Pittala, William Koehler, Jonathan Deans, Daniel Salinas, Martin Bringmann, Katharina Sophia Volz, Berk Kapicioglu
• Abstract summary: We propose a novel machine learning method that identifies disease genes on such graphs. We show that our algorithms outperform its closest state-of-the-art competitor in disease gene identification by 24.1%. We also show that we achieve higher precision than Open Targets, the leading initiative for target identification, with respect to predicting drug targets in clinical trials for Parkinson's disease.
• Score: 0.3078691410268859
• License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
• Abstract: Identification of disease genes, which are a set of genes associated with a disease, plays an important role in understanding and curing diseases. In this paper, we present a biomedical knowledge graph designed specifically for this problem, propose a novel machine learning method that identifies disease genes on such graphs by leveraging recent advances in network biology and graph representation learning, study the effects of various relation types on prediction performance, and empirically demonstrate that our algorithms outperform its closest state-of-the-art competitor in disease gene identification by 24.1%. We also show that we achieve higher precision than Open Targets, the leading initiative for target identification, with respect to predicting drug targets in clinical trials for Parkinson's disease.

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