Comparing Spectroscopy Measurements in the Prediction of in Vitro Dissolution Profile using Artificial Neural Networks

• URL: http://arxiv.org/abs/2210.10292v1
• Date: Wed, 19 Oct 2022 04:34:04 GMT
• Title: Comparing Spectroscopy Measurements in the Prediction of in Vitro Dissolution Profile using Artificial Neural Networks
• Authors: Mohamed Azouz Mrad, Krist\'of Csorba, Dori\'an L\'aszl\'o Galata, Zsombor Krist\'of Nagy and Brigitta Nagy
• Abstract summary: Dissolution testing is part of the target product quality that is essential in approving new products in the pharmaceutical industry. The prediction of the dissolution profile based on spectroscopic data is an alternative to the current destructive and time-consuming method. Raman and near-infrared (NIR) spectroscopies are two fast and complementary methods that provide information on the tablets' physical and chemical properties.
• Score: 0.0
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: Dissolution testing is part of the target product quality that is essential in approving new products in the pharmaceutical industry. The prediction of the dissolution profile based on spectroscopic data is an alternative to the current destructive and time-consuming method. Raman and near-infrared (NIR) spectroscopies are two fast and complementary methods that provide information on the tablets' physical and chemical properties and can help predict their dissolution profiles. This work aims to compare the information collected by these spectroscopy methods to support the decision of which measurements should be used so that the accuracy requirement of the industry is met. Artificial neural network models were created, in which the spectroscopy data and the measured compression curves were used as an input individually and in different combinations in order to estimate the dissolution profiles. Results showed that using only the NIR transmission method along with the compression force data or the Raman and NIR reflection methods, the dissolution profile was estimated within the acceptance limits of the f2 similarity factor. Adding further spectroscopy measurements increased the prediction accuracy.

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