Trajectory-oriented optimization of stochastic epidemiological models

• URL: http://arxiv.org/abs/2305.03926v3
• Date: Wed, 13 Sep 2023 20:41:24 GMT
• Title: Trajectory-oriented optimization of stochastic epidemiological models
• Authors: Arindam Fadikar, Mickael Binois, Nicholson Collier, Abby Stevens, Kok Ben Toh, Jonathan Ozik
• Abstract summary: Epidemiological models must be calibrated to ground truth for downstream tasks. We propose a class of Gaussian process (GP) surrogates along with an optimization strategy based on Thompson sampling. This Trajectory Oriented Optimization (TOO) approach produces actual trajectories close to the empirical observations.
• Score: 0.873811641236639
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: Epidemiological models must be calibrated to ground truth for downstream tasks such as producing forward projections or running what-if scenarios. The meaning of calibration changes in case of a stochastic model since output from such a model is generally described via an ensemble or a distribution. Each member of the ensemble is usually mapped to a random number seed (explicitly or implicitly). With the goal of finding not only the input parameter settings but also the random seeds that are consistent with the ground truth, we propose a class of Gaussian process (GP) surrogates along with an optimization strategy based on Thompson sampling. This Trajectory Oriented Optimization (TOO) approach produces actual trajectories close to the empirical observations instead of a set of parameter settings where only the mean simulation behavior matches with the ground truth.

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