Lightweight Large Language Model for Medication Enquiry: Med-Pal

• URL: http://arxiv.org/abs/2407.12822v1
• Date: Tue, 2 Jul 2024 03:32:39 GMT
• Title: Lightweight Large Language Model for Medication Enquiry: Med-Pal
• Authors: Kabilan Elangovan, Jasmine Chiat Ling Ong, Liyuan Jin, Benjamin Jun Jie Seng, Yu Heng Kwan, Lit Soo Tan, Ryan Jian Zhong, Justina Koi Li Ma, YuHe Ke, Nan Liu, Kathleen M Giacomini, Daniel Shu Wei Ting,
• Abstract summary: Large Language Models (LLMs) have emerged as a potential solution to assist digital health development with patient education. We trained and validated Med-Pal, a medication domain-specific LLM-chatbot fine-tuned with a fine-grained and expert curated dataset.
• Score: 2.3095351248532268
• License: http://creativecommons.org/publicdomain/zero/1.0/
• Abstract: Large Language Models (LLMs) have emerged as a potential solution to assist digital health development with patient education, commonly medication-related enquires. We trained and validated Med-Pal, a medication domain-specific LLM-chatbot fine-tuned with a fine-grained and expert curated dataset from a selection of five light-weighted open-source LLMs of smaller parameter size (7 billion or less) regarding computational constraints and prioritizing operational efficiency. A multi-disciplinary team performed a clinical evaluation of LLMs responses using the SCORE criteria, focusing on safety, accuracy, bias, reproducibility, and ease of understanding. Best performing light-weighted LLM was chosen as Med-Pal for further engineering with guard-railing using adversarial prompting. Med-Pal and existing light-weighted LLMs, including pretrained Biomistral and finetuned Meerkat, were validated on an independent dataset on a broad range of medication-related questions (231 in total), 12 different question types across 14 different medication classes. Mistral-7b emerged as the top performer among selected lightweight LLMs, achieving the highest median score of 14 and 71.9% high-quality responses in accuracy and safety domains, hence chosen as the backbone LLM for Med-Pal. When compared against Biomistral, Med-pal outperformed in generating responses appropriate for patient communication, with significant reductions bias and errors typical of general LLMs. Comparable performance was observed when comparing Med-Pal with Meerkat. Med-Pal showcases the feasibility of developing and employing fine-tuned light-weighted LLMs to enhance digital health communications.

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