ExDDI: Explaining Drug-Drug Interaction Predictions with Natural Language

• URL: http://arxiv.org/abs/2409.05592v1
• Date: Mon, 9 Sep 2024 13:23:14 GMT
• Title: ExDDI: Explaining Drug-Drug Interaction Predictions with Natural Language
• Authors: Zhaoyue Sun, Jiazheng Li, Gabriele Pergola, Yulan He,
• Abstract summary: We propose to generate natural language explanations for DDI predictions. We have collected DDI explanations from DDInter and DrugBank. Our models can provide accurate explanations for unknown DDIs between known drugs.
• Score: 19.426453222204714
• License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
• Abstract: Predicting unknown drug-drug interactions (DDIs) is crucial for improving medication safety. Previous efforts in DDI prediction have typically focused on binary classification or predicting DDI categories, with the absence of explanatory insights that could enhance trust in these predictions. In this work, we propose to generate natural language explanations for DDI predictions, enabling the model to reveal the underlying pharmacodynamics and pharmacokinetics mechanisms simultaneously as making the prediction. To do this, we have collected DDI explanations from DDInter and DrugBank and developed various models for extensive experiments and analysis. Our models can provide accurate explanations for unknown DDIs between known drugs. This paper contributes new tools to the field of DDI prediction and lays a solid foundation for further research on generating explanations for DDI predictions.

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