Generating crossmodal gene expression from cancer histopathology improves multimodal AI predictions

• URL: http://arxiv.org/abs/2502.00568v3
• Date: Tue, 11 Feb 2025 12:25:42 GMT
• Title: Generating crossmodal gene expression from cancer histopathology improves multimodal AI predictions
• Authors: Samiran Dey, Christopher R. S. Banerji, Partha Basuchowdhuri, Sanjoy K. Saha, Deepak Parashar, Tapabrata Chakraborti,
• Abstract summary: We show that genomic expressions synthesized from digital histopathology jointly predict cancer grading and patient survival risk with high accuracy. PathGen code is available for open use by the research community through GitHub at https://github.com/Samiran-Dey/PathGen.
• Score: 1.0225653612678713
• License:
• Abstract: Emerging research has highlighted that artificial intelligence based multimodal fusion of digital pathology and transcriptomic features can improve cancer diagnosis (grading/subtyping) and prognosis (survival risk) prediction. However, such direct fusion for joint decision is impractical in real clinical settings, where histopathology is still the gold standard for diagnosis and transcriptomic tests are rarely requested, at least in the public healthcare system. With our novel diffusion based crossmodal generative AI model PathGen, we show that genomic expressions synthesized from digital histopathology jointly predicts cancer grading and patient survival risk with high accuracy (state-of-the-art performance), certainty (through conformal coverage guarantee) and interpretability (through distributed attention maps). PathGen code is available for open use by the research community through GitHub at https://github.com/Samiran-Dey/PathGen.

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