Intermediate State Formation of Topologically Associated Chromatin Domains using Quantum Annealing

• URL: http://arxiv.org/abs/2505.23289v1
• Date: Thu, 29 May 2025 09:40:39 GMT
• Title: Intermediate State Formation of Topologically Associated Chromatin Domains using Quantum Annealing
• Authors: Tobias Kempe, S. M. Ali Tabei, Mohammad H. Ansari,
• Abstract summary: Topologically Associating Chromatic Domains are spatially distinct regions that regulate transcription by segregating genomic elements.<n>Recent models represent a spin system, where nucleosomes are treated as discrete-state variables.<n>We present a quantum annealing (QA) approach to efficiently sample states, embedding an epigenetic Ising model into the topology of D-Wave quantum processors.
• Score: 0.0
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: Topologically Associating Chromatic Domains are spatially distinct chromatin regions that regulate transcription by segregating active and inactive genomic elements. Empirical studies show that their formation correlates with local patterns of epigenetic markers, yet the precise mechanisms linking 1D epigenetic landscapes to 3D chromatin folding remain unclear. Recent models represent chromatin as a spin system, where nucleosomes are treated as discrete-state variables coupled by interaction strengths derived from genomic and epigenomic data. Classical samplers struggle with these models due to high frustration and dense couplings. Here, we present a quantum annealing (QA) approach to efficiently sample chromatin states, embedding an epigenetic Ising model into the topology of D-Wave quantum processors.

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