Towards Practical Alzheimer's Disease Diagnosis: A Lightweight and Interpretable Spiking Neural Model

• URL: http://arxiv.org/abs/2506.09695v2
• Date: Mon, 07 Jul 2025 08:47:01 GMT
• Title: Towards Practical Alzheimer's Disease Diagnosis: A Lightweight and Interpretable Spiking Neural Model
• Authors: Changwei Wu, Yifei Chen, Yuxin Du, Jinying Zong, Jie Dong, Mingxuan Liu, Yong Peng, Jin Fan, Feiwei Qin, Changmiao Wang,
• Abstract summary: Early diagnosis of Alzheimer's Disease (AD) is vital yet hindered by subjective assessments and the high cost of multimodal imaging modalities.<n>As a brain-inspired paradigm, spiking neural networks (SNNs) are inherently well-suited for modeling the sparse, event-driven patterns of neural degeneration in AD.<n>We propose FasterSNN, a hybrid neural architecture that integrates biologically inspired LIF neurons with region-adaptive convolution and multi-scale spiking attention.
• Score: 7.289867430801027
• License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
• Abstract: Early diagnosis of Alzheimer's Disease (AD), especially at the mild cognitive impairment (MCI) stage, is vital yet hindered by subjective assessments and the high cost of multimodal imaging modalities. Although deep learning methods offer automated alternatives, their energy inefficiency and computational demands limit real-world deployment, particularly in resource-constrained settings. As a brain-inspired paradigm, spiking neural networks (SNNs) are inherently well-suited for modeling the sparse, event-driven patterns of neural degeneration in AD, offering a promising foundation for interpretable and low-power medical diagnostics. However, existing SNNs often suffer from weak expressiveness and unstable training, which restrict their effectiveness in complex medical tasks. To address these limitations, we propose FasterSNN, a hybrid neural architecture that integrates biologically inspired LIF neurons with region-adaptive convolution and multi-scale spiking attention. This design enables sparse, efficient processing of 3D MRI while preserving diagnostic accuracy. Experiments on benchmark datasets demonstrate that FasterSNN achieves competitive performance with substantially improved efficiency and stability, supporting its potential for practical AD screening. Our source code is available at https://github.com/wuchangw/FasterSNN.

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