PathoHR: Hierarchical Reasoning for Vision-Language Models in Pathology

• URL: http://arxiv.org/abs/2509.06105v2
• Date: Tue, 30 Sep 2025 11:39:52 GMT
• Title: PathoHR: Hierarchical Reasoning for Vision-Language Models in Pathology
• Authors: Yating Huang, Ziyan Huang, Lintao Xiang, Qijun Yang, Hujun Yin,
• Abstract summary: Current vision-language (VL) models often struggle to capture the complex reasoning required for interpreting structured pathological reports.<n>We propose PathoHR-Bench, a novel benchmark designed to evaluate VL models' abilities in hierarchical semantic understanding and compositional reasoning within the pathology domain.<n>We further introduce a pathology-specific VL training scheme that generates enhanced and perturbed samples for multimodal contrastive learning.
• Score: 3.459714932882085
• License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
• Abstract: Accurate analysis of pathological images is essential for automated tumor diagnosis but remains challenging due to high structural similarity and subtle morphological variations in tissue images. Current vision-language (VL) models often struggle to capture the complex reasoning required for interpreting structured pathological reports. To address these limitations, we propose PathoHR-Bench, a novel benchmark designed to evaluate VL models' abilities in hierarchical semantic understanding and compositional reasoning within the pathology domain. Results of this benchmark reveal that existing VL models fail to effectively model intricate cross-modal relationships, hence limiting their applicability in clinical setting. To overcome this, we further introduce a pathology-specific VL training scheme that generates enhanced and perturbed samples for multimodal contrastive learning. Experimental evaluations demonstrate that our approach achieves state-of-the-art performance on PathoHR-Bench and six additional pathology datasets, highlighting its effectiveness in fine-grained pathology representation.

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