MedReflect: Teaching Medical LLMs to Self-Improve via Reflective Correction
- URL: http://arxiv.org/abs/2510.03687v1
- Date: Sat, 04 Oct 2025 06:00:48 GMT
- Title: MedReflect: Teaching Medical LLMs to Self-Improve via Reflective Correction
- Authors: Yue Huang, Yanyuan Chen, Dexuan Xu, Weihua Yue, Huamin Zhang, Meikang Qiu, Yu Huang,
- Abstract summary: We introduce MedReflect, a framework designed to inspire large language models with a physician-like reflective thinking mode.<n>We demonstrate that MedReflect enables cost-efficient medical dataset construction.<n>Our results provide evidence that LLMs can learn to solve specialized medical problems via self-reflection and self-improve.
- Score: 23.71420855072473
- License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
- Abstract: Medical problem solving demands expert knowledge and intricate reasoning. Recent studies of large language models (LLMs) attempt to ease this complexity by introducing external knowledge verification through retrieval-augmented generation or by training on reasoning datasets. However, these approaches suffer from drawbacks such as retrieval overhead and high annotation costs, and they heavily rely on substituted external assistants to reach limited performance in medical field. In this paper, we introduce MedReflect, a generalizable framework designed to inspire LLMs with a physician-like reflective thinking mode. MedReflect generates a single-pass reflection chain that includes initial hypothesis generation, self-questioning, self-answering and decision refinement. This self-verified and self-reflective nature releases large language model's latent capability in medical problem-solving without external retrieval or heavy annotation. We demonstrate that MedReflect enables cost-efficient medical dataset construction: with merely 2,000 randomly sampled training examples and a light fine-tuning, this approach achieves notable absolute accuracy improvements across a series of medical benchmarks while cutting annotation requirements. Our results provide evidence that LLMs can learn to solve specialized medical problems via self-reflection and self-improve, reducing reliance on external supervision and extensive task-specific fine-tuning data.
Related papers
- Self-MedRAG: a Self-Reflective Hybrid Retrieval-Augmented Generation Framework for Reliable Medical Question Answering [39.146761527401424]
Self-MedRAG is a self-reflective hybrid framework designed to mimic the iterative hypothesis-verification process of clinical reasoning.<n>It integrates a hybrid retrieval strategy, combining sparse (BM25) and dense (Contriever) retrievers via Reciprocal Rank Fusion.<n>It employs a generator to produce answers with supporting rationales, which are then assessed by a lightweight self-reflection module.
arXiv Detail & Related papers (2026-01-08T02:56:04Z) - MedAlign: A Synergistic Framework of Multimodal Preference Optimization and Federated Meta-Cognitive Reasoning [52.064286116035134]
We develop MedAlign, a framework to ensure visually accurate LVLM responses for Medical Visual Question Answering (Med-VQA)<n>We first propose a multimodal Direct Preference Optimization (mDPO) objective to align preference learning with visual context.<n>We then design a Retrieval-Aware Mixture-of-Experts (RA-MoE) architecture that utilizes image and text similarity to route queries to a specialized and context-augmented LVLM.
arXiv Detail & Related papers (2025-10-24T02:11:05Z) - Uncertainty-Driven Expert Control: Enhancing the Reliability of Medical Vision-Language Models [52.2001050216955]
Existing methods aim to enhance the performance of Medical Vision Language Model (MedVLM) by adjusting model structure, fine-tuning with high-quality data, or through preference fine-tuning.<n>We propose an expert-in-the-loop framework named Expert-Controlled-Free Guidance (Expert-CFG) to align MedVLM with clinical expertise without additional training.
arXiv Detail & Related papers (2025-07-12T09:03:30Z) - GEMeX-ThinkVG: Towards Thinking with Visual Grounding in Medical VQA via Reinforcement Learning [50.94508930739623]
Medical visual question answering aims to support clinical decision-making by enabling models to answer natural language questions based on medical images.<n>Current methods still suffer from limited answer reliability and poor interpretability, impairing the ability of clinicians and patients to understand and trust model-generated answers.<n>This work first proposes a Thinking with Visual Grounding dataset wherein the answer generation is decomposed into intermediate reasoning steps.<n>We introduce a novel verifiable reward mechanism for reinforcement learning to guide post-training, improving the alignment between the model's reasoning process and its final answer.
arXiv Detail & Related papers (2025-06-22T08:09:58Z) - Structured Outputs Enable General-Purpose LLMs to be Medical Experts [50.02627258858336]
Large language models (LLMs) often struggle with open-ended medical questions.<n>We propose a novel approach utilizing structured medical reasoning.<n>Our approach achieves the highest Factuality Score of 85.8, surpassing fine-tuned models.
arXiv Detail & Related papers (2025-03-05T05:24:55Z) - Limitations of Large Language Models in Clinical Problem-Solving Arising from Inflexible Reasoning [3.3482359447109866]
Large Language Models (LLMs) have attained human-level accuracy on medical question-answer (QA) benchmarks.<n>Their limitations in navigating open-ended clinical scenarios have recently been shown.<n>We present the medical abstraction and reasoning corpus (M-ARC)<n>We find that LLMs, including current state-of-the-art o1 and Gemini models, perform poorly compared to physicians on M-ARC.
arXiv Detail & Related papers (2025-02-05T18:14:27Z) - Med-R$^2$: Crafting Trustworthy LLM Physicians via Retrieval and Reasoning of Evidence-Based Medicine [40.651632523697536]
Large Language Models (LLMs) have exhibited remarkable capabilities in clinical scenarios.<n>We introduce Med-R2, a novel framework that adheres to the Evidence-Based Medicine (EBM) process.<n>Our experiments indicate that Med-R2 achieves a 14.74% improvement over vanilla RAG methods and even a 3.32% enhancement compared to fine-tuning strategies.
arXiv Detail & Related papers (2025-01-21T04:40:43Z) - Towards Mitigating Hallucination in Large Language Models via
Self-Reflection [63.2543947174318]
Large language models (LLMs) have shown promise for generative and knowledge-intensive tasks including question-answering (QA) tasks.
This paper analyses the phenomenon of hallucination in medical generative QA systems using widely adopted LLMs and datasets.
arXiv Detail & Related papers (2023-10-10T03:05:44Z) - Large Language Models Cannot Self-Correct Reasoning Yet [78.16697476530994]
Large Language Models (LLMs) have emerged as a groundbreaking technology with their unparalleled text generation capabilities.
Concerns persist regarding the accuracy and appropriateness of their generated content.
A contemporary methodology, self-correction, has been proposed as a remedy to these issues.
arXiv Detail & Related papers (2023-10-03T04:56:12Z) - MKRAG: Medical Knowledge Retrieval Augmented Generation for Medical Question Answering [45.84961106102445]
Large Language Models (LLMs) often perform poorly on domain-specific tasks such as medical question answering (QA)
We propose a comprehensive retrieval strategy to extract medical facts from an external knowledge base, and then inject them into the LLM's query prompt.
Our retrieval-augmented Vicuna-7B model exhibited an accuracy improvement from 44.46% to 48.54%.
arXiv Detail & Related papers (2023-09-27T21:26:03Z) - Self-Verification Improves Few-Shot Clinical Information Extraction [73.6905567014859]
Large language models (LLMs) have shown the potential to accelerate clinical curation via few-shot in-context learning.
They still struggle with issues regarding accuracy and interpretability, especially in mission-critical domains such as health.
Here, we explore a general mitigation framework using self-verification, which leverages the LLM to provide provenance for its own extraction and check its own outputs.
arXiv Detail & Related papers (2023-05-30T22:05:11Z)
This list is automatically generated from the titles and abstracts of the papers in this site.
This site does not guarantee the quality of this site (including all information) and is not responsible for any consequences.