Transfer Orthology Networks

• URL: http://arxiv.org/abs/2510.15837v1
• Date: Fri, 17 Oct 2025 17:24:55 GMT
• Title: Transfer Orthology Networks
• Authors: Vikash Singh,
• Abstract summary: Transfer Orthology Networks (TRON) is a neural network architecture designed for cross-species transfer learning.<n>TRON learns a linear transformation that maps gene expression from the source to the target species' gene space.<n>We are in the process of collecting cross-species transcriptomic/phenotypic data to gain experimental validation of the TRON architecture.
• Score: 0.09229852843814061
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: We present Transfer Orthology Networks (TRON), a novel neural network architecture designed for cross-species transfer learning. TRON leverages orthologous relationships, represented as a bipartite graph between species, to guide knowledge transfer. Specifically, we prepend a learned species conversion layer, whose weights are masked by the biadjacency matrix of this bipartite graph, to a pre-trained feedforward neural network that predicts a phenotype from gene expression data in a source species. This allows for efficient transfer of knowledge to a target species by learning a linear transformation that maps gene expression from the source to the target species' gene space. The learned weights of this conversion layer offer a potential avenue for interpreting functional orthology, providing insights into how genes across species contribute to the phenotype of interest. TRON offers a biologically grounded and interpretable approach to cross-species transfer learning, paving the way for more effective utilization of available transcriptomic data. We are in the process of collecting cross-species transcriptomic/phenotypic data to gain experimental validation of the TRON architecture.

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