AI-assisted workflow enables rapid, high-fidelity breast cancer clinical trial eligibility prescreening

• URL: http://arxiv.org/abs/2511.05696v1
• Date: Fri, 07 Nov 2025 20:27:05 GMT
• Title: AI-assisted workflow enables rapid, high-fidelity breast cancer clinical trial eligibility prescreening
• Authors: Jacob T. Rosenthal, Emma Hahesy, Sulov Chalise, Menglei Zhu, Mert R. Sabuncu, Lior Z. Braunstein, Anyi Li,
• Abstract summary: We developed MSK-MATCH (Memorial Sloan Kettering Multi-Agent Trial Coordination Hub), an AI system for automated eligibility screening from clinical text.<n>MSK-MATCH integrates a large language model with a curated oncology trial knowledge base and retrieval-augmented architecture.<n>In a retrospective dataset of 88,518 clinical documents from 731 patients across six breast cancer trials, MSK-MATCH automatically resolved 61.9% of cases and triaged 38.1% for human review.
• Score: 4.008304844602351
• License: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Abstract: Clinical trials play an important role in cancer care and research, yet participation rates remain low. We developed MSK-MATCH (Memorial Sloan Kettering Multi-Agent Trial Coordination Hub), an AI system for automated eligibility screening from clinical text. MSK-MATCH integrates a large language model with a curated oncology trial knowledge base and retrieval-augmented architecture providing explanations for all AI predictions grounded in source text. In a retrospective dataset of 88,518 clinical documents from 731 patients across six breast cancer trials, MSK-MATCH automatically resolved 61.9% of cases and triaged 38.1% for human review. This AI-assisted workflow achieved 98.6% accuracy, 98.4% sensitivity, and 98.7% specificity for patient-level eligibility classification, matching or exceeding performance of the human-only and AI-only comparisons. For the triaged cases requiring manual review, prepopulating eligibility screens with AI-generated explanations reduced screening time from 20 minutes to 43 seconds at an average cost of $0.96 per patient-trial pair.

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