Generalist Large Language Models Outperform Clinical Tools on Medical Benchmarks

• URL: http://arxiv.org/abs/2512.01191v1
• Date: Mon, 01 Dec 2025 02:14:43 GMT
• Title: Generalist Large Language Models Outperform Clinical Tools on Medical Benchmarks
• Authors: Krithik Vishwanath, Mrigayu Ghosh, Anton Alyakin, Daniel Alexander Alber, Yindalon Aphinyanaphongs, Eric Karl Oermann,
• Abstract summary: Generalist models consistently outperformed clinical tools.<n>OpenEvidence and UpToDate Expert AI demonstrated deficits in completeness, communication quality, context awareness, and systems-based safety reasoning.
• Score: 1.2773749417703923
• License: http://creativecommons.org/licenses/by-nc-sa/4.0/
• Abstract: Specialized clinical AI assistants are rapidly entering medical practice, often framed as safer or more reliable than general-purpose large language models (LLMs). Yet, unlike frontier models, these clinical tools are rarely subjected to independent, quantitative evaluation, creating a critical evidence gap despite their growing influence on diagnosis, triage, and guideline interpretation. We assessed two widely deployed clinical AI systems (OpenEvidence and UpToDate Expert AI) against three state-of-the-art generalist LLMs (GPT-5, Gemini 3 Pro, and Claude Sonnet 4.5) using a 1,000-item mini-benchmark combining MedQA (medical knowledge) and HealthBench (clinician-alignment) tasks. Generalist models consistently outperformed clinical tools, with GPT-5 achieving the highest scores, while OpenEvidence and UpToDate demonstrated deficits in completeness, communication quality, context awareness, and systems-based safety reasoning. These findings reveal that tools marketed for clinical decision support may often lag behind frontier LLMs, underscoring the urgent need for transparent, independent evaluation before deployment in patient-facing workflows.

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