Dense Feature Learning via Linear Structure Preservation in Medical Data
- URL: http://arxiv.org/abs/2602.07706v1
- Date: Sat, 07 Feb 2026 21:23:35 GMT
- Title: Dense Feature Learning via Linear Structure Preservation in Medical Data
- Authors: Yuanyun Zhang, Mingxuan Zhang, Siyuan Li, Zihan Wang, Haoran Chen, Wenbo Zhou, Shi Li,
- Abstract summary: Deep learning models for medical data are typically trained using task specific objectives that encourage representations to collapse onto a small number of discriminative directions.<n>We propose dense feature learning, a representation centric framework that explicitly shapes the linear structure of medical embeddings.
- Score: 30.77691570199694
- License: http://creativecommons.org/licenses/by/4.0/
- Abstract: Deep learning models for medical data are typically trained using task specific objectives that encourage representations to collapse onto a small number of discriminative directions. While effective for individual prediction problems, this paradigm underutilizes the rich structure of clinical data and limits the transferability, stability, and interpretability of learned features. In this work, we propose dense feature learning, a representation centric framework that explicitly shapes the linear structure of medical embeddings. Our approach operates directly on embedding matrices, encouraging spectral balance, subspace consistency, and feature orthogonality through objectives defined entirely in terms of linear algebraic properties. Without relying on labels or generative reconstruction, dense feature learning produces representations with higher effective rank, improved conditioning, and greater stability across time. Empirical evaluations across longitudinal EHR data, clinical text, and multimodal patient representations demonstrate consistent improvements in downstream linear performance, robustness, and subspace alignment compared to supervised and self supervised baselines. These results suggest that learning to span clinical variation may be as important as learning to predict clinical outcomes, and position representation geometry as a first class objective in medical AI.
Related papers
- ClinStructor: AI-Powered Structuring of Unstructured Clinical Texts [3.073796943975155]
We present ClinStructor, a pipeline that leverages large language models (LLMs) to convert clinical free-text into structured, task-specific question-answer pairs prior to predictive modeling.<n>Our method substantially enhances transparency and controllability and only leads to a modest reduction in predictive performance.
arXiv Detail & Related papers (2025-11-14T21:21:16Z) - Timely Clinical Diagnosis through Active Test Selection [49.091903570068155]
We propose ACTMED (Adaptive Clinical Test selection via Model-based Experimental Design) to better emulate real-world diagnostic reasoning.<n>LLMs act as flexible simulators, generating plausible patient state distributions and supporting belief updates without requiring structured, task-specific training data.<n>We evaluate ACTMED on real-world datasets and show it can optimize test selection to improve diagnostic accuracy, interpretability, and resource use.
arXiv Detail & Related papers (2025-10-21T18:10:45Z) - Self-Supervised Anatomical Consistency Learning for Vision-Grounded Medical Report Generation [61.350584471060756]
Vision-grounded medical report generation aims to produce clinically accurate descriptions of medical images.<n>We propose Self-Supervised Anatomical Consistency Learning (SS-ACL) to align generated reports with corresponding anatomical regions.<n>SS-ACL constructs a hierarchical anatomical graph inspired by the invariant top-down inclusion structure of human anatomy.
arXiv Detail & Related papers (2025-09-30T08:59:06Z) - Interpretable Clinical Classification with Kolgomorov-Arnold Networks [70.72819760172744]
Kolmogorov-Arnold Networks (KANs) offer intrinsic interpretability through transparent, symbolic representations.<n>KANs support built-in patient-level insights, intuitive visualizations, and nearest-patient retrieval.<n>These results position KANs as a promising step toward trustworthy AI that clinicians can understand, audit, and act upon.
arXiv Detail & Related papers (2025-09-20T17:21:58Z) - Clinical semantics for lung cancer prediction [1.6744500686720596]
Existing clinical prediction models often represent patient data using features that ignore semantic relationships between clinical concepts.<n>This study integrates domain-specific semantic information by mapping the SNOMED medical term hierarchy into a low-dimensional hyperbolic space.
arXiv Detail & Related papers (2025-08-20T11:29:47Z) - Leveraging the Structure of Medical Data for Improved Representation Learning [12.175375511821352]
Building generalizable medical AI systems requires pretraining strategies that are data-efficient and domain-aware.<n>We propose a self-supervised framework that leverages the inherent structure of medical datasets.<n>We show strong performance compared to supervised objectives and baselines being trained without leveraging structure.
arXiv Detail & Related papers (2025-07-01T11:14:45Z) - Evaluating the Fairness of the MIMIC-IV Dataset and a Baseline
Algorithm: Application to the ICU Length of Stay Prediction [65.268245109828]
This paper uses the MIMIC-IV dataset to examine the fairness and bias in an XGBoost binary classification model predicting the ICU length of stay.
The research reveals class imbalances in the dataset across demographic attributes and employs data preprocessing and feature extraction.
The paper concludes with recommendations for fairness-aware machine learning techniques for mitigating biases and the need for collaborative efforts among healthcare professionals and data scientists.
arXiv Detail & Related papers (2023-12-31T16:01:48Z) - Language Model Training Paradigms for Clinical Feature Embeddings [1.4513150969598638]
We use self-supervised training paradigms for language models to learn high-quality clinical feature embeddings.
We visualize the learnt embeddings via unsupervised dimension reduction techniques and observe a high degree of consistency with prior clinical knowledge.
arXiv Detail & Related papers (2023-11-01T18:23:12Z) - TREEMENT: Interpretable Patient-Trial Matching via Personalized Dynamic
Tree-Based Memory Network [54.332862955411656]
Clinical trials are critical for drug development but often suffer from expensive and inefficient patient recruitment.
In recent years, machine learning models have been proposed for speeding up patient recruitment via automatically matching patients with clinical trials.
We introduce a dynamic tree-based memory network model named TREEMENT to provide accurate and interpretable patient trial matching.
arXiv Detail & Related papers (2023-07-19T12:35:09Z) - A Multimodal Transformer: Fusing Clinical Notes with Structured EHR Data
for Interpretable In-Hospital Mortality Prediction [8.625186194860696]
We provide a novel multimodal transformer to fuse clinical notes and structured EHR data for better prediction of in-hospital mortality.
To improve interpretability, we propose an integrated gradients (IG) method to select important words in clinical notes.
We also investigate the significance of domain adaptive pretraining and task adaptive fine-tuning on the Clinical BERT.
arXiv Detail & Related papers (2022-08-09T03:49:52Z) - LifeLonger: A Benchmark for Continual Disease Classification [59.13735398630546]
We introduce LifeLonger, a benchmark for continual disease classification on the MedMNIST collection.
Task and class incremental learning of diseases address the issue of classifying new samples without re-training the models from scratch.
Cross-domain incremental learning addresses the issue of dealing with datasets originating from different institutions while retaining the previously obtained knowledge.
arXiv Detail & Related papers (2022-04-12T12:25:05Z) - Trajectories, bifurcations and pseudotime in large clinical datasets:
applications to myocardial infarction and diabetes data [94.37521840642141]
We suggest a semi-supervised methodology for the analysis of large clinical datasets, characterized by mixed data types and missing values.
The methodology is based on application of elastic principal graphs which can address simultaneously the tasks of dimensionality reduction, data visualization, clustering, feature selection and quantifying the geodesic distances (pseudotime) in partially ordered sequences of observations.
arXiv Detail & Related papers (2020-07-07T21:04:55Z)
This list is automatically generated from the titles and abstracts of the papers in this site.
This site does not guarantee the quality of this site (including all information) and is not responsible for any consequences.