EFGPP: Exploratory framework for genotype-phenotype prediction

• URL: http://arxiv.org/abs/2605.02954v1
• Date: Sat, 02 May 2026 12:42:40 GMT
• Title: EFGPP: Exploratory framework for genotype-phenotype prediction
• Abstract summary: We present EFSTP, a framework for generating, ranking, and combining multiple types of data for genotype-to-phenotype prediction.<n>We applied EFSTP to migraine prediction using UK Biobank data from 733 individuals.
• Score: 0.0
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: Predicting complex human traits from genetic data is challenging because different genetic, clinical, and molecular data sources often contain different parts of the signal. Here, we present EFGPP, a reproducible framework for generating, ranking, and combining multiple types of data for genotype-to-phenotype prediction. We applied EFGPP to migraine prediction using UK Biobank data from 733 individuals. The framework combined genotype-derived features, principal components, clinical and metabolomic covariates, and polygenic risk scores generated from migraine and depression GWAS using PLINK, PRSice-2, AnnoPred, and LDAK-GWAS. The best single data type achieved a test AUC of 0.644, while combining multiple data types improved performance to 0.688 using migraine-focused inputs and 0.663 using cross-trait depression-derived inputs. Genetic features alone did not outperform the covariates-only baseline, but genotype-derived features performed better than PRS alone, and depression-derived PRS showed useful predictive signal. Overall, EFGPP provides a practical proof-of-concept framework for prioritising and integrating heterogeneous genetic data sources for complex phenotype prediction.

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