APCyc: Property-Informed Design of Cyclic Peptides via Automated Cyclization

• URL: http://arxiv.org/abs/2606.12991v1
• Date: Thu, 11 Jun 2026 07:26:16 GMT
• Title: APCyc: Property-Informed Design of Cyclic Peptides via Automated Cyclization
• Abstract summary: We introduce APCyc, a target-aware de novo cyclic peptide generation framework that explicitly models cyclization.<n>We show that APCyc learns target-dependent cyclization preferences, and enables effective and controllable multi-property optimization.
• Score: 20.344878555028227
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: Cyclic peptides represent a promising class of therapeutic compounds in modern drug discovery, often offering improved stability and binding affinity. However, the de novo design of cyclic peptides remains challenging because methods must identify pocket-adaptive cyclization patterns and linkage sites while simultaneously controlling drug-relevant properties. This challenge is particularly pronounced for recent generative models trained predominantly on linear peptide data, which may fail to capture cyclization-specific constraints. To address the limitation, we introduce APCyc, a target-aware de novo cyclic peptide generation framework that explicitly models cyclization and jointly optimizes multiple essential physicochemical properties. By using an expanded residue vocabulary and explicitly encoding cyclization-site and linkage-type information, APCyc learns cyclization-aware representations and leverages Bayesian posterior guidance to steer sampling toward cyclic peptides satisfying multiple property objectives. Experimental results demonstrate that our model learns target-dependent cyclization preferences, and enables effective and controllable multi-property optimization for cyclic peptide design. The source code of this paper is available at https://github.com/HKUSTGZ-ML4Health-Lab/APCyc.

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