Task-guided cross-subject latent alignment: a multi-encoder-decoder VAE
- URL: http://arxiv.org/abs/2606.15989v1
- Date: Sun, 14 Jun 2026 19:30:11 GMT
- Title: Task-guided cross-subject latent alignment: a multi-encoder-decoder VAE
- Abstract summary: We introduce a Multi-Encoder-Decoder Variational Autoencoder (MED-VAE) that achieves cross-subject alignment without shared stimuli.<n>We show that MED-VAE creates common latent spaces with superior semantic organisation, achieving higher cross-subject alignment than common methods.<n>We also show that this superior alignment directly enables cross-subject neural prediction, as demonstrated via cross-subject image decoding.
- Score: 1.936594951038608
- License: http://creativecommons.org/licenses/by/4.0/
- Abstract: Aligning neural activity across subjects offers the promise of discovering shared computational principles and generalizable decoders. However, traditional alignment methods require shared stimuli across subjects, a constraint that limits applicability to naturalistic paradigms with limited or non-overlapping data. We introduce a Multi-Encoder-Decoder Variational Autoencoder (MED-VAE) that achieves cross-subject alignment without shared stimuli by anchoring representations to a common scaffold provided by a pretrained ANN. Using the Natural Scenes Dataset, we show that MED-VAE creates common latent spaces with superior semantic organisation, achieving higher cross-subject alignment than common methods while maintaining robust generalisation to held-out stimuli where traditional methods degrade. Reconstructing from these common spaces back to each subject's original neural space, MED-VAE preserves equal stimulus-driven signal in its cross-subject latent space. Finally, we show that this superior alignment directly enables cross-subject neural prediction, as demonstrated via cross-subject image decoding. In summary, we introduce a framework to identify generalisable common subspaces for cross-subject predictions and downstream tasks, demonstrated here for visual cortex responses to static images.
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