CARE: Confidence-Aware Reasoning for Reliable Medical VQA
- URL: http://arxiv.org/abs/2608.10964v1
- Date: Tue, 11 Aug 2026 14:28:52 GMT
- Title: CARE: Confidence-Aware Reasoning for Reliable Medical VQA
- Abstract summary: Reinforcement Fine-Tuning (RFT) has enabled medical Multimodal Large Language Models (MLLMs) to produce Chain-of-Thought (CoT) reasoning for visual question answering.<n>We propose $textbfCARE$, a $textbfC$onfidence-$textbfA$ware medical $textbfRE$asoning framework that jointly optimize accuracy and calibration.
- Score: 17.225779954453163
- License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
- Abstract: Reinforcement Fine-Tuning (RFT) has enabled medical Multimodal Large Language Models (MLLMs) to produce Chain-of-Thought (CoT) reasoning for visual question answering, yet these models suffer from $\textit{confidence miscalibration}$---a systematic gap between expressed certainty and actual diagnostic accuracy that undermines clinical trust. We propose $\textbf{CARE}$, a $\textbf{C}$onfidence-$\textbf{A}$ware medical $\textbf{RE}$asoning framework that jointly optimizes accuracy and calibration through a dual-stage pipeline. First, a scalable Medical-CoT synthesis provides structured cold-start data for Supervised Fine-Tuning. Second, Group Relative Policy Optimization (GRPO) with a novel $\textbf{Confidence-Aware Reward (CAR)}$ mechanism ties the model's confidence to diagnostic correctness within the reward signal. Across three Medical VQA benchmarks, $\textbf{CARE}$ achieves the highest diagnostic accuracy while obtaining the lowest Expected Calibration Error and Hallucination Rate, establishing a foundation for trustworthy clinical decision support. Our code is available at https://github.com/anotherbricki/CARE.
Related papers
- Scaling with Confidence: Calibrating Confidence of LLMs for Adaptive Test Time Scaling [2.8793525226737327]
A novel reinforcement learning algorithm integrates correctness, calibration and dataset-informed reference accuracy rewards together.<n>C3RL enhances calibration without sacrificing accuracy, outperforming the current state-of-the-art method in both performance and calibration metrics.<n>Experiments show that CAS surpasses majority voting on both in-domain and out-of-domain datasets while reducing the inference budget by up to 12.33 times.
arXiv Detail & Related papers (2026-07-02T02:29:33Z) - Just how sure are you? Improving Verbalized Uncertainty Calibration in Medical VQA [0.16383644639245779]
Multimodal large language models (MLLMs) applied to Medical Visual Question Answering (VQA) tend to produce overconfident outputs regardless of actual correctness.<n>This work proposes a training based framework that finetunes MLLMs to improve their calibration using a composite loss function.
arXiv Detail & Related papers (2026-06-25T13:33:58Z) - Confidence-Aware Alignment Makes Reasoning LLMs More Reliable [65.44962502963378]
We introduce CASPO, a framework that aligns token-level confidence with step-wise logical correctness without training a separate reward model.<n>During inference, we propose Confidence-aware Thought (CaT), which dynamically prunes uncertain reasoning branches with negligible O(V) latency.<n>Experiments across ten benchmarks and multiple model families show that CASPO consistently improves reasoning reliability and inference efficiency.
arXiv Detail & Related papers (2026-05-08T07:08:25Z) - Towards Trustworthy Depression Estimation via Disentangled Evidential Learning [50.22167852149165]
We propose EviDep, an evidential learning framework that jointly quantifies depression severity.<n>EviDep enforces strict information integrity to guarantee robust evidence synthesis.<n>It achieves state-of-the-art predictive accuracy and superior uncertainty calibration, delivering a robust fail-safe mechanism for trustworthy clinical screening.
arXiv Detail & Related papers (2026-04-17T13:27:11Z) - Knowing When to Answer: Adaptive Confidence Refinement for Reliable Audio-Visual Question Answering [15.39457034915546]
We present a formal problem formulation for textitReliable Audio-Visual Question Answering ($mathcalR$-AVQA), where we prefer abstention over answering incorrectly.<n>We propose Adaptive Confidence Refinement (ACR), a lightweight method to further enhance the performance of $mathcalR$-AVQA.
arXiv Detail & Related papers (2026-02-04T08:35:33Z) - Epistemic Context Learning: Building Trust the Right Way in LLM-Based Multi-Agent Systems [94.9141394384021]
Individual agents in multi-agent systems often lack robustness, tending to blindly conform to misleading peers.<n>We show this weakness stems from both sycophancy and inadequate ability to evaluate peer reliability.<n>We first formalize the learning problem of history-aware reference, introducing the historical interactions of peers as additional input.<n>We then develop Epistemic Context Learning (ECL), a reasoning framework that conditions predictions on explicitly-built peer profiles from history.
arXiv Detail & Related papers (2026-01-29T13:59:32Z) - Towards Reliable Medical LLMs: Benchmarking and Enhancing Confidence Estimation of Large Language Models in Medical Consultation [97.36081721024728]
We propose the first benchmark for assessing confidence in multi-turn interaction during realistic medical consultations.<n>Our benchmark unifies three types of medical data for open-ended diagnostic generation.<n>We present MedConf, an evidence-grounded linguistic self-assessment framework.
arXiv Detail & Related papers (2026-01-22T04:51:39Z) - Evaluating Reasoning Faithfulness in Medical Vision-Language Models using Multimodal Perturbations [19.488236277427358]
Vision-language models (VLMs) often produce chain-of-thought (CoT) explanations that sound plausible yet fail to reflect the underlying decision process.<n>We present a clinically grounded framework for chest X-ray visual question answering (VQA) that probes CoT faithfulness via controlled text and image modifications.
arXiv Detail & Related papers (2025-10-13T09:28:22Z) - Sample Smart, Not Hard: Correctness-First Decoding for Better Reasoning in LLMs [72.82403830490084]
We argue that the decoding rule should be calibrated by correctness, not confidence alone.<n>We propose simple strategies that achieve this goal: Greedy-Threshold makes sampling greedy at very low confidence steps.<n>Together, our findings challenge prevailings about decoding under uncertainty and show gains across math and general reasoning benchmarks.
arXiv Detail & Related papers (2025-10-07T14:46:12Z) - Reinforcement Learning with Verifiable yet Noisy Rewards under Imperfect Verifiers [90.50039419576807]
Reinforcement Learning with Verifiable Rewards (RLVR) trains policies against automated verifiers to avoid costly human labeling.<n>To reduce vulnerability to verifier hacking, many RLVR systems collapse rewards to binary $0,1$ during training.<n>This choice carries a cost: it introduces textitfalse negatives (rejecting correct answers, FNs) and textitfalse positives (accepting incorrect ones, FPs)
arXiv Detail & Related papers (2025-10-01T13:56:44Z) - Probabilistically Tightened Linear Relaxation-based Perturbation Analysis for Neural Network Verification [83.25968588249776]
We present a novel framework that combines over-approximation techniques from LiRPA-based approaches with a sampling-based method to compute tight intermediate reachable sets.<n>With negligible computational overhead, $textttPT-LiRPA$ exploiting the estimated reachable sets, significantly tightens the lower and upper linear bounds of a neural network's output.
arXiv Detail & Related papers (2025-07-07T18:45:53Z) - Data-Driven Calibration of Prediction Sets in Large Vision-Language Models Based on Inductive Conformal Prediction [0.0]
We propose a model-agnostic uncertainty quantification method that integrates dynamic threshold calibration and cross-modal consistency verification.<n>We show that the framework achieves stable performance across varying calibration-to-test split ratios, underscoring its robustness for real-world deployment in healthcare, autonomous systems, and other safety-sensitive domains.<n>This work bridges the gap between theoretical reliability and practical applicability in multi-modal AI systems, offering a scalable solution for hallucination detection and uncertainty-aware decision-making.
arXiv Detail & Related papers (2025-04-24T15:39:46Z) - Deep Reinforcement Learning for Cost-Effective Medical Diagnosis [41.10546022107126]
We use reinforcement learning to find a dynamic policy that selects lab test panels sequentially based on previous observations.
We propose a Semi-Model-based Deep Diagnosis Policy Optimization framework that is compatible with end-to-end training and online learning.
SM-DDPO is tested on diverse clinical tasks: ferritin abnormality detection, sepsis mortality prediction, and acute kidney injury diagnosis.
arXiv Detail & Related papers (2023-02-20T19:47:25Z)
This list is automatically generated from the titles and abstracts of the papers in this site.
This site does not guarantee the quality of this site (including all information) and is not responsible for any consequences.