A Unified Geometric Framework for Developmental Analysis of Spatial Transcriptomic Data

• URL: http://arxiv.org/abs/2608.15306v1
• Date: Sat, 15 Aug 2026 16:19:58 GMT
• Title: A Unified Geometric Framework for Developmental Analysis of Spatial Transcriptomic Data
• Abstract summary: High-resolution single-cell and transcriptomic technologies provide snapshots of heterogeneous cellular states.<n> temporal and spatial dynamics must be inferred from independently sampled, unaligned cell populations.<n>We introduce a geometric framework for analyzing thetemporal evolution of gene expression networks through embeddings in Gromov--Wasserstein (GW) space.
• Score: 38.40052829128497
• License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
• Abstract: High-throughput single-cell and spatial transcriptomic technologies provide high-resolution snapshots of heterogeneous cellular states, but their destructive nature prevents repeated measurements of the same cells over time. Consequently, temporal and spatial dynamics must be inferred from independently sampled, unaligned cell populations, making it challenging to reconstruct developmental trajectories. Optimal transport (OT) offers a geometric framework for aligning cell populations and inferring developmental trajectories, but many existing approaches focus on modeling the evolution of distributions of cells in gene expression space rather than the relational structure encoded by gene expression networks. To address this limitation, we introduce a geometric framework for analyzing the spatiotemporal evolution of gene expression networks through embeddings in Gromov--Wasserstein (GW) space. By representing each developmental stage as a graph combining gene expression and spatial proximity, our approach enables comparisons of network structure across time, continuous interpolation between developmental stages via GW geodesics, and quantification of network-level changes using Ollivier-Ricci curvature. We evaluate our framework on a spatiotemporal transcriptomic \textit{Drosophila} dataset and show that GW geodesic interpolations reproduce main trends in curvature dynamics observed in empirical gene expression networks. Agreement with higher-order Co-Optimal Transport (COOT) distances, which jointly represent spatial and temporal information, further validates the framework and suggests that hypernetwork representations successfully record salient biological changes across time. In general, our approach provides a unified geometric approach to study dynamically evolving biological networks.

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