Survival Cluster Analysis

• URL: http://arxiv.org/abs/2003.00355v1
• Date: Sat, 29 Feb 2020 22:41:21 GMT
• Title: Survival Cluster Analysis
• Authors: Paidamoyo Chapfuwa, Chunyuan Li, Nikhil Mehta, Lawrence Carin, Ricardo Henao
• Abstract summary: There is an unmet need in survival analysis for identifying subpopulations with distinct risk profiles. An approach that addresses this need is likely to improve characterization of individual outcomes.
• Score: 93.50540270973927
• License: http://creativecommons.org/licenses/by-nc-sa/4.0/
• Abstract: Conventional survival analysis approaches estimate risk scores or individualized time-to-event distributions conditioned on covariates. In practice, there is often great population-level phenotypic heterogeneity, resulting from (unknown) subpopulations with diverse risk profiles or survival distributions. As a result, there is an unmet need in survival analysis for identifying subpopulations with distinct risk profiles, while jointly accounting for accurate individualized time-to-event predictions. An approach that addresses this need is likely to improve characterization of individual outcomes by leveraging regularities in subpopulations, thus accounting for population-level heterogeneity. In this paper, we propose a Bayesian nonparametrics approach that represents observations (subjects) in a clustered latent space, and encourages accurate time-to-event predictions and clusters (subpopulations) with distinct risk profiles. Experiments on real-world datasets show consistent improvements in predictive performance and interpretability relative to existing state-of-the-art survival analysis models.

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