Millimetre-scale magnetocardiography of living rats using a solid-state quantum sensor

• URL: http://arxiv.org/abs/2105.11676v1
• Date: Tue, 25 May 2021 05:27:52 GMT
• Title: Millimetre-scale magnetocardiography of living rats using a solid-state quantum sensor
• Authors: Keigo Arai, Akihiro Kuwahata, Daisuke Nishitani, Ikuya Fujisaki, Ryoma Matsuki, Zhonghao Xin, Yuki Nishio, Xinyu Cao, Yuji Hatano, Shinobu Onoda, Chikara Shinei, Masashi Miyakawa, Takashi Taniguchi, Masatoshi Yamazaki, Tokuyuki Teraji, Takeshi Ohshima, Mutsuko Hatano, Masaki Sekino, Takayuki Iwasaki
• Abstract summary: A key challenge in cardiology is the non-invasive imaging of electric current propagation occurring in the cardiovascular system at an intra-cardiac scale. Here we demonstrate millimetre-scale magnetocardiography of living rats using a solid-state quantum sensor based on nitrogen-vacancy centres in diamond.
• Score: 1.0264250032103253
• License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
• Abstract: A key challenge in cardiology is the non-invasive imaging of electric current propagation occurring in the cardiovascular system at an intra-cardiac scale. A promising approach for directly mapping the current dynamics is to monitor the associated stray magnetic field. However, in this magnetic field approach, the spatial resolution deteriorates significantly as the standoff distance between the target and the sensor increases. Existing sensors usually remain relatively far from the target and provide only centimetre-scale resolution because their operating temperature is not biocompatible. Here we demonstrate millimetre-scale magnetocardiography of living rats using a solid-state quantum sensor based on nitrogen-vacancy centres in diamond. The essence of the method is a millimetre proximity from the sensor to heart surface, which enhances the cardiac magnetic field to greater than nanoteslas and allows the mapping of these signals with intra-cardiac resolution. From the acquired magnetic images, we also estimate the source electric current vector, flowing from the right atria base via the Purkinje fibre bundle to the left ventricular apex. Our results establish the solid-state quantum sensor's capability to probe cardiac magnetic signals from mammalian animals and reveal their intra-cardiac electrodynamics. This technique will enable the study of the origin and progression of myriad cardiac arrhythmias including flutter, fibrillation, and tachycardia.

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