Measuring kinetic parameters using quantum plasmonic sensing
- URL: http://arxiv.org/abs/2107.06214v2
- Date: Fri, 13 May 2022 12:19:56 GMT
- Title: Measuring kinetic parameters using quantum plasmonic sensing
- Authors: K. T. Mpofu, C. Lee, G. E. M. Maguire, H. G. Kruger and M. S. Tame
- Abstract summary: We study theoretically the use of quantum sensing techniques for measuring the kinetic parameters of molecular interactions.
The results may help in the design of more precise quantum-based sensors for studying kinetics in the life sciences.
- Score: 0.0
- License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
- Abstract: The measurement of parameters that describe kinetic processes is important in
the study of molecular interactions. It enables a deeper understanding of the
physical mechanisms underlying how different biological entities interact with
each other, such as viruses with cells, vaccines with antibodies, or new drugs
with specific diseases. In this work, we study theoretically the use of quantum
sensing techniques for measuring the kinetic parameters of molecular
interactions. The sensor we consider is a plasmonic resonance sensor -- a
label-free photonic sensor that is one of the most widely used in research and
industry. The first type of interaction we study is the antigen BSA interacting
with antibody IgG1, which provides a large sensor response. The second type is
the enzyme carbonic anhydrase interacting with the tumor growth inhibitor
benzenesulfonamide, which produces a small sensor response. For both types of
interaction we consider the use of two-mode Fock states, squeezed vacuum states
and squeezed displaced states. We find that these quantum states offer an
enhancement in the measurement precision of kinetic parameters when compared to
that obtained with classical light. The results may help in the design of more
precise quantum-based sensors for studying kinetics in the life sciences.
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