U-Net-and-a-half: Convolutional network for biomedical image
segmentation using multiple expert-driven annotations
- URL: http://arxiv.org/abs/2108.04658v1
- Date: Tue, 10 Aug 2021 13:08:39 GMT
- Title: U-Net-and-a-half: Convolutional network for biomedical image
segmentation using multiple expert-driven annotations
- Authors: Yichi Zhang, Jesper Kers, Clarissa A. Cassol, Joris J. Roelofs, Najia
Idrees, Alik Farber, Samir Haroon, Kevin P. Daly, Suvranu Ganguli, Vipul C.
Chitalia, Vijaya B. Kolachalama
- Abstract summary: Deep learning systems for biomedical segmentation often require access to expert-driven, manually annotated datasets.
Here we present a deep neural network, defined as U-Net-and-a-half, which can simultaneously learn from annotations performed by multiple experts on the same set of images.
- Score: 6.682450741319984
- License: http://creativecommons.org/licenses/by/4.0/
- Abstract: Development of deep learning systems for biomedical segmentation often
requires access to expert-driven, manually annotated datasets. If more than a
single expert is involved in the annotation of the same images, then the
inter-expert agreement is not necessarily perfect, and no single expert
annotation can precisely capture the so-called ground truth of the regions of
interest on all images. Also, it is not trivial to generate a reference
estimate using annotations from multiple experts. Here we present a deep neural
network, defined as U-Net-and-a-half, which can simultaneously learn from
annotations performed by multiple experts on the same set of images.
U-Net-and-a-half contains a convolutional encoder to generate features from the
input images, multiple decoders that allow simultaneous learning from image
masks obtained from annotations that were independently generated by multiple
experts, and a shared low-dimensional feature space. To demonstrate the
applicability of our framework, we used two distinct datasets from digital
pathology and radiology, respectively. Specifically, we trained two separate
models using pathologist-driven annotations of glomeruli on whole slide images
of human kidney biopsies (10 patients), and radiologist-driven annotations of
lumen cross-sections of human arteriovenous fistulae obtained from
intravascular ultrasound images (10 patients), respectively. The models based
on U-Net-and-a-half exceeded the performance of the traditional U-Net models
trained on single expert annotations alone, thus expanding the scope of
multitask learning in the context of biomedical image segmentation.
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