Generating Synthetic Mixed-type Longitudinal Electronic Health Records for Artificial Intelligent Applications

• URL: http://arxiv.org/abs/2112.12047v1
• Date: Wed, 22 Dec 2021 17:17:34 GMT
• Title: Generating Synthetic Mixed-type Longitudinal Electronic Health Records for Artificial Intelligent Applications
• Authors: Jin Li, Benjamin J. Cairns, Jingsong Li, Tingting Zhu
• Abstract summary: generative adversarial network (GAN) entitled EHR-M-GAN which synthesizes textitmixed-type timeseries EHR data. We have validated EHR-M-GAN on three publicly-available intensive care unit databases with records from a total of 141,488 unique patients.
• Score: 9.374416143268892
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: The recent availability of electronic health records (EHRs) have provided enormous opportunities to develop artificial intelligence (AI) algorithms. However, patient privacy has become a major concern that limits data sharing across hospital settings and subsequently hinders the advances in AI. \textit{Synthetic data}, which benefits from the development and proliferation of generative models, has served as a promising substitute for real patient EHR data. However, the current generative models are limited as they only generate \textit{single type} of clinical data, i.e., either continuous-valued or discrete-valued. In this paper, we propose a generative adversarial network (GAN) entitled EHR-M-GAN which synthesizes \textit{mixed-type} timeseries EHR data. EHR-M-GAN is capable of capturing the multidimensional, heterogeneous, and correlated temporal dynamics in patient trajectories. We have validated EHR-M-GAN on three publicly-available intensive care unit databases with records from a total of 141,488 unique patients, and performed privacy risk evaluation of the proposed model. EHR-M-GAN has demonstrated its superiority in performance over state-of-the-art benchmarks for synthesizing clinical timeseries with high fidelity. Notably, prediction models for outcomes of intensive care performed significantly better when training data was augmented with the addition of EHR-M-GAN-generated timeseries. EHR-M-GAN may have use in developing AI algorithms in resource-limited settings, lowering the barrier for data acquisition while preserving patient privacy.

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