Nanodiamond quantum sensors reveal temperature variation associated to hippocampal neurons firing

• URL: http://arxiv.org/abs/2204.10182v1
• Date: Thu, 31 Mar 2022 09:39:57 GMT
• Title: Nanodiamond quantum sensors reveal temperature variation associated to hippocampal neurons firing
• Authors: G. Petrini, G. Tomagra, E. Bernardi, E. Moreva, P. Traina, A. Marcantoni, F. Picollo, K. Kvakova, P. Cigler, I.P. Degiovanni, V. Carabelli, M. Genovese
• Abstract summary: We use a nanoscale thermometer based on optically detected magnetic resonance in nanodiamonds to detect temperature variations (1degC) associated with potentiation and depletion of neuronal firing. The results pave the way to a systematic study of the generation of localized temperature gradients.
• Score: 0.0
• License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
• Abstract: Temperature is one of the most relevant parameters for the regulation of intracellular processes. Measuring localized subcellular temperature gradients is fundamental for a deeper understanding of cell function, such as the genesis of action potentials, and cell metabolism. Here, we detect for the first time temperature variations (1{\deg}C) associated with potentiation and depletion of neuronal firing, exploiting a nanoscale thermometer based on optically detected magnetic resonance in nanodiamonds. Our results provide a tool for assessing neuronal spiking activity under physiological and pathological conditions and, conjugated with the high sensitivity of this technique (in perspective sensitive to < 0.1{\deg}C variations), pave the way to a systematic study of the generation of localized temperature gradients. Furthermore, they prompt further studies explaining in detail the physiological mechanism originating this effect.

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