Unsupervised Domain Adaptation for Automated Knee Osteoarthritis
Phenotype Classification
- URL: http://arxiv.org/abs/2212.07023v1
- Date: Wed, 14 Dec 2022 04:26:32 GMT
- Title: Unsupervised Domain Adaptation for Automated Knee Osteoarthritis
Phenotype Classification
- Authors: Junru Zhong, Yongcheng Yao, Donal G. Cahill, Fan Xiao, Siyue Li, Jack
Lee, Kevin Ki-Wai Ho, Michael Tim-Yun Ong, James F. Griffith and Weitian Chen
- Abstract summary: The aim of this study was to demonstrate the utility of unsupervised domain adaptation (UDA) in automated knee osteoarthritis (OA) phenotype classification using a small dataset.
- Score: 0.8288807499147146
- License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
- Abstract: Purpose: The aim of this study was to demonstrate the utility of unsupervised
domain adaptation (UDA) in automated knee osteoarthritis (OA) phenotype
classification using a small dataset (n=50). Materials and Methods: For this
retrospective study, we collected 3,166 three-dimensional (3D) double-echo
steady-state magnetic resonance (MR) images from the Osteoarthritis Initiative
dataset and 50 3D turbo/fast spin-echo MR images from our institute (in 2020
and 2021) as the source and target datasets, respectively. For each patient,
the degree of knee OA was initially graded according to the MRI Osteoarthritis
Knee Score (MOAKS) before being converted to binary OA phenotype labels. The
proposed UDA pipeline included (a) pre-processing, which involved automatic
segmentation and region-of-interest cropping; (b) source classifier training,
which involved pre-training phenotype classifiers on the source dataset; (c)
target encoder adaptation, which involved unsupervised adaption of the source
encoder to the target encoder and (d) target classifier validation, which
involved statistical analysis of the target classification performance
evaluated by the area under the receiver operating characteristic curve
(AUROC), sensitivity, specificity and accuracy. Additionally, a classifier was
trained without UDA for comparison. Results: The target classifier trained with
UDA achieved improved AUROC, sensitivity, specificity and accuracy for both
knee OA phenotypes compared with the classifier trained without UDA.
Conclusion: The proposed UDA approach improves the performance of automated
knee OA phenotype classification for small target datasets by utilising a
large, high-quality source dataset for training. The results successfully
demonstrated the advantages of the UDA approach in classification on small
datasets.
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