Comprehensive analysis of gene expression profiles to radiation exposure reveals molecular signatures of low-dose radiation response

• URL: http://arxiv.org/abs/2301.01769v1
• Date: Tue, 3 Jan 2023 20:35:20 GMT
• Title: Comprehensive analysis of gene expression profiles to radiation exposure reveals molecular signatures of low-dose radiation response
• Authors: Xihaier Luo and Sean McCorkle and Gilchan Park and Vanessa Lopez-Marrero and Shinjae Yoo and Edward R. Dougherty and Xiaoning Qian and Francis J. Alexander and Byung-Jun Yoon
• Abstract summary: We perform a comprehensive pathway-based analysis of gene expression profiles in response to low-dose radiation exposure. We employ a statistical framework to determine whether a specific group of genes display coordinated expression patterns that are modulated in a manner consistent with the radiation level.
• Score: 15.434518016385764
• License: http://creativecommons.org/licenses/by-nc-sa/4.0/
• Abstract: There are various sources of ionizing radiation exposure, where medical exposure for radiation therapy or diagnosis is the most common human-made source. Understanding how gene expression is modulated after ionizing radiation exposure and investigating the presence of any dose-dependent gene expression patterns have broad implications for health risks from radiotherapy, medical radiation diagnostic procedures, as well as other environmental exposure. In this paper, we perform a comprehensive pathway-based analysis of gene expression profiles in response to low-dose radiation exposure, in order to examine the potential mechanism of gene regulation underlying such responses. To accomplish this goal, we employ a statistical framework to determine whether a specific group of genes belonging to a known pathway display coordinated expression patterns that are modulated in a manner consistent with the radiation level. Findings in our study suggest that there exist complex yet consistent signatures that reflect the molecular response to radiation exposure, which differ between low-dose and high-dose radiation.

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