A New Deep Learning and XAI-Based Algorithm for Features Selection in Genomics

• URL: http://arxiv.org/abs/2303.16914v1
• Date: Wed, 29 Mar 2023 16:44:13 GMT
• Title: A New Deep Learning and XAI-Based Algorithm for Features Selection in Genomics
• Authors: Carlo Adornetto and Gianluigi Greco
• Abstract summary: The paper proposes a novel algorithm to perform Feature Selection on genomic-scale data. Results of the application on a Chronic Lymphocytic Leukemia dataset evidence the effectiveness of the algorithm.
• Score: 5.787117733071415
• License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
• Abstract: In the field of functional genomics, the analysis of gene expression profiles through Machine and Deep Learning is increasingly providing meaningful insight into a number of diseases. The paper proposes a novel algorithm to perform Feature Selection on genomic-scale data, which exploits the reconstruction capabilities of autoencoders and an ad-hoc defined Explainable Artificial Intelligence-based score in order to select the most informative genes for diagnosis, prognosis, and precision medicine. Results of the application on a Chronic Lymphocytic Leukemia dataset evidence the effectiveness of the algorithm, by identifying and suggesting a set of meaningful genes for further medical investigation.

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