Rapid prediction of lab-grown tissue properties using deep learning
- URL: http://arxiv.org/abs/2303.18017v1
- Date: Fri, 31 Mar 2023 12:49:37 GMT
- Title: Rapid prediction of lab-grown tissue properties using deep learning
- Authors: Allison E. Andrews, Hugh Dickinson and James P. Hague
- Abstract summary: We use machine learning tools to predict the role of mechanobiology in the self-organisation of cell-laden hydrogels grown in tethered moulds.
The machine learning algorithm is significantly faster than the biophysical method.
Future extensions for scaffolds and 3D bioprinting will open additional applications.
- Score: 0.0
- License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
- Abstract: The interactions between cells and the extracellular matrix are vital for the
self-organisation of tissues. In this paper we present proof-of-concept to use
machine learning tools to predict the role of this mechanobiology in the
self-organisation of cell-laden hydrogels grown in tethered moulds. We develop
a process for the automated generation of mould designs with and without key
symmetries. We create a large training set with $N=6500$ cases by running
detailed biophysical simulations of cell-matrix interactions using the
contractile network dipole orientation (CONDOR) model for the self-organisation
of cellular hydrogels within these moulds. These are used to train an
implementation of the \texttt{pix2pix} deep learning model, reserving $740$
cases that were unseen in the training of the neural network for training and
validation. Comparison between the predictions of the machine learning
technique and the reserved predictions from the biophysical algorithm show that
the machine learning algorithm makes excellent predictions. The machine
learning algorithm is significantly faster than the biophysical method, opening
the possibility of very high throughput rational design of moulds for
pharmaceutical testing, regenerative medicine and fundamental studies of
biology. Future extensions for scaffolds and 3D bioprinting will open
additional applications.
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