Model Based Reinforcement Learning for Personalized Heparin Dosing

• URL: http://arxiv.org/abs/2304.10000v1
• Date: Wed, 19 Apr 2023 22:37:12 GMT
• Title: Model Based Reinforcement Learning for Personalized Heparin Dosing
• Authors: Qinyang He and Yonatan Mintz
• Abstract summary: We propose a framework to address the challenge of optimizing personalized heparin doses. We use a predictive model parameterized individually by patient to predict future therapeutic effects. We then leverage this model using a scenario generation based approach that is capable of ensuring patient safety.
• Score: 0.0
• License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
• Abstract: A key challenge in sequential decision making is optimizing systems safely under partial information. While much of the literature has focused on the cases of either partially known states or partially known dynamics, it is further exacerbated in cases where both states and dynamics are partially known. Computing heparin doses for patients fits this paradigm since the concentration of heparin in the patient cannot be measured directly and the rates at which patients metabolize heparin vary greatly between individuals. While many proposed solutions are model free, they require complex models and have difficulty ensuring safety. However, if some of the structure of the dynamics is known, a model based approach can be leveraged to provide safe policies. In this paper we propose such a framework to address the challenge of optimizing personalized heparin doses. We use a predictive model parameterized individually by patient to predict future therapeutic effects. We then leverage this model using a scenario generation based approach that is capable of ensuring patient safety. We validate our models with numerical experiments by comparing the predictive capabilities of our model against existing machine learning techniques and demonstrating how our dosing algorithm can treat patients in a simulated ICU environment.

Related papers

• Individualized Dosing Dynamics via Neural Eigen Decomposition [51.62933814971523]
  We introduce the Neural Eigen Differential Equation algorithm (NESDE) NESDE provides individualized modeling, tunable generalization to new treatment policies, and fast, continuous, closed-form prediction. We demonstrate the robustness of NESDE in both synthetic and real medical problems, and use the learned dynamics to publish simulated medical gym environments.
  arXiv  Detail & Related papers  (2023-06-24T17:01:51Z)
• Benchmarking Heterogeneous Treatment Effect Models through the Lens of Interpretability [82.29775890542967]
  Estimating personalized effects of treatments is a complex, yet pervasive problem. Recent developments in the machine learning literature on heterogeneous treatment effect estimation gave rise to many sophisticated, but opaque, tools. We use post-hoc feature importance methods to identify features that influence the model's predictions.
  arXiv  Detail & Related papers  (2022-06-16T17:59:05Z)
• Bridging the Gap Between Patient-specific and Patient-independent Seizure Prediction via Knowledge Distillation [7.2666838978096875]
  Existing approaches typically train models in a patient-specific fashion due to the highly personalized characteristics of epileptic signals. A patient-specific model can then be obtained with the help of distilled knowledge and additional personalized data. Five state-of-the-art seizure prediction methods are trained on the CHB-MIT sEEG database with our proposed scheme.
  arXiv  Detail & Related papers  (2022-02-25T10:30:29Z)
• Development of patients triage algorithm from nationwide COVID-19 registry data based on machine learning [1.0323063834827415]
  This paper provides the development processes of the severity assessment model using machine learning techniques. Model only requires basic patients' basic personal data, allowing for them to judge their own severity. We aim to establish a medical system that allows patients to check their own severity and informs them to visit the appropriate clinic center based on the past treatment details of other patients with similar severity.
  arXiv  Detail & Related papers  (2021-09-18T19:56:27Z)
• Integrating Expert ODEs into Neural ODEs: Pharmacology and Disease Progression [71.7560927415706]
  latent hybridisation model (LHM) integrates a system of expert-designed ODEs with machine-learned Neural ODEs to fully describe the dynamics of the system. We evaluate LHM on synthetic data as well as real-world intensive care data of COVID-19 patients.
  arXiv  Detail & Related papers  (2021-06-05T11:42:45Z)
• A Twin Neural Model for Uplift [59.38563723706796]
  Uplift is a particular case of conditional treatment effect modeling. We propose a new loss function defined by leveraging a connection with the Bayesian interpretation of the relative risk. We show our proposed method is competitive with the state-of-the-art in simulation setting and on real data from large scale randomized experiments.
  arXiv  Detail & Related papers  (2021-05-11T16:02:39Z)
• An Optimal Control Approach to Learning in SIDARTHE Epidemic model [67.22168759751541]
  We propose a general approach for learning time-variant parameters of dynamic compartmental models from epidemic data. We forecast the epidemic evolution in Italy and France.
  arXiv  Detail & Related papers  (2020-10-28T10:58:59Z)
• A General Framework for Survival Analysis and Multi-State Modelling [70.31153478610229]
  We use neural ordinary differential equations as a flexible and general method for estimating multi-state survival models. We show that our model exhibits state-of-the-art performance on popular survival data sets and demonstrate its efficacy in a multi-state setting.
  arXiv  Detail & Related papers  (2020-06-08T19:24:54Z)

This list is automatically generated from the titles and abstracts of the papers in this site.

This site does not guarantee the quality of this site (including all information) and is not responsible for any consequences.