Unsupervised Discovery of 3D Hierarchical Structure with Generative
Diffusion Features
- URL: http://arxiv.org/abs/2305.00067v2
- Date: Tue, 10 Oct 2023 04:01:38 GMT
- Title: Unsupervised Discovery of 3D Hierarchical Structure with Generative
Diffusion Features
- Authors: Nurislam Tursynbek, Marc Niethammer
- Abstract summary: We show that features of diffusion models capture different hierarchy levels in 3D biomedical images.
We train a predictive unsupervised segmentation network that encourages the decomposition of 3D volumes into meaningful nested subvolumes.
Our models achieve better performance than prior unsupervised structure discovery approaches on challenging synthetic datasets and on a real-world brain tumor MRI dataset.
- Score: 22.657405088126012
- License: http://creativecommons.org/licenses/by/4.0/
- Abstract: Inspired by recent findings that generative diffusion models learn
semantically meaningful representations, we use them to discover the intrinsic
hierarchical structure in biomedical 3D images using unsupervised segmentation.
We show that features of diffusion models from different stages of a
U-Net-based ladder-like architecture capture different hierarchy levels in 3D
biomedical images. We design three losses to train a predictive unsupervised
segmentation network that encourages the decomposition of 3D volumes into
meaningful nested subvolumes that represent a hierarchy. First, we pretrain 3D
diffusion models and use the consistency of their features across subvolumes.
Second, we use the visual consistency between subvolumes. Third, we use the
invariance to photometric augmentations as a regularizer. Our models achieve
better performance than prior unsupervised structure discovery approaches on
challenging biologically-inspired synthetic datasets and on a real-world brain
tumor MRI dataset.
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