OneProt: Towards Multi-Modal Protein Foundation Models

• URL: http://arxiv.org/abs/2411.04863v1
• Date: Thu, 07 Nov 2024 16:54:54 GMT
• Title: OneProt: Towards Multi-Modal Protein Foundation Models
• Authors: Klemens Flöge, Srisruthi Udayakumar, Johanna Sommer, Marie Piraud, Stefan Kesselheim, Vincent Fortuin, Stephan Günneman, Karel J van der Weg, Holger Gohlke, Alina Bazarova, Erinc Merdivan,
• Abstract summary: We introduce OneProt, a multi-modal AI for proteins that integrates structural, sequence, alignment, and binding site data. It surpasses state-of-the-art methods in various downstream tasks, including metal ion binding classification, gene-ontology annotation, and enzyme function prediction. This work expands multi-modal capabilities in protein models, paving the way for applications in drug discovery, biocatalytic reaction planning, and protein engineering.
• Score: 5.440531199006399
• License:
• Abstract: Recent AI advances have enabled multi-modal systems to model and translate diverse information spaces. Extending beyond text and vision, we introduce OneProt, a multi-modal AI for proteins that integrates structural, sequence, alignment, and binding site data. Using the ImageBind framework, OneProt aligns the latent spaces of modality encoders along protein sequences. It demonstrates strong performance in retrieval tasks and surpasses state-of-the-art methods in various downstream tasks, including metal ion binding classification, gene-ontology annotation, and enzyme function prediction. This work expands multi-modal capabilities in protein models, paving the way for applications in drug discovery, biocatalytic reaction planning, and protein engineering.

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