Real-world validation of a multimodal LLM-powered pipeline for High-Accuracy Clinical Trial Patient Matching leveraging EHR data

• URL: http://arxiv.org/abs/2503.15374v1
• Date: Wed, 19 Mar 2025 16:12:11 GMT
• Title: Real-world validation of a multimodal LLM-powered pipeline for High-Accuracy Clinical Trial Patient Matching leveraging EHR data
• Authors: Anatole Callies, Quentin Bodinier, Philippe Ravaud, Kourosh Davarpanah,
• Abstract summary: Patient recruitment in clinical trials is hindered by complex eligibility criteria and labor-intensive chart reviews.<n>We introduce an integration-free, LLM-powered pipeline that automates patient-trial matching using unprocessed documents extracted from EHRs.<n>Our approach leverages (1) the new reasoning-LLM paradigm, enabling the assessment of even the most complex criteria, (2) visual capabilities of latest LLMs to interpret medical records without lossy image-to-text conversions, and (3) multimodal embeddings for efficient medical record search.
• Score: 0.0
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: Background: Patient recruitment in clinical trials is hindered by complex eligibility criteria and labor-intensive chart reviews. Prior research using text-only models have struggled to address this problem in a reliable and scalable way due to (1) limited reasoning capabilities, (2) information loss from converting visual records to text, and (3) lack of a generic EHR integration to extract patient data. Methods: We introduce a broadly applicable, integration-free, LLM-powered pipeline that automates patient-trial matching using unprocessed documents extracted from EHRs. Our approach leverages (1) the new reasoning-LLM paradigm, enabling the assessment of even the most complex criteria, (2) visual capabilities of latest LLMs to interpret medical records without lossy image-to-text conversions, and (3) multimodal embeddings for efficient medical record search. The pipeline was validated on the n2c2 2018 cohort selection dataset (288 diabetic patients) and a real-world dataset composed of 485 patients from 30 different sites matched against 36 diverse trials. Results: On the n2c2 dataset, our method achieved a new state-of-the-art criterion-level accuracy of 93\%. In real-world trials, the pipeline yielded an accuracy of 87\%, undermined by the difficulty to replicate human decision-making when medical records lack sufficient information. Nevertheless, users were able to review overall eligibility in under 9 minutes per patient on average, representing an 80\% improvement over traditional manual chart reviews. Conclusion: This pipeline demonstrates robust performance in clinical trial patient matching without requiring custom integration with site systems or trial-specific tailoring, thereby enabling scalable deployment across sites seeking to leverage AI for patient matching.

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