Histomorphology-driven multi-instance learning for breast cancer WSI classification

• URL: http://arxiv.org/abs/2503.17983v1
• Date: Sun, 23 Mar 2025 08:25:29 GMT
• Title: Histomorphology-driven multi-instance learning for breast cancer WSI classification
• Authors: Baizhi Wang, Rui Yan, Wenxin Ma, Xu Zhang, Yuhao Wang, Xiaolong Li, Yunjie Gu, Zihang Jiang, S. Kevin Zhou,
• Abstract summary: Current whole slide image (WSI) classification methods struggle to effectively incorporate histomorphology information.<n>We propose a novel framework that explicitly incorporates histomorphology into WSI classification.
• Score: 37.70113409383555
• License: http://creativecommons.org/publicdomain/zero/1.0/
• Abstract: Histomorphology is crucial in breast cancer diagnosis. However, existing whole slide image (WSI) classification methods struggle to effectively incorporate histomorphology information, limiting their ability to capture key and fine-grained pathological features. To address this limitation, we propose a novel framework that explicitly incorporates histomorphology (tumor cellularity, cellular morphology, and tissue architecture) into WSI classification. Specifically, our approach consists of three key components: (1) estimating the importance of tumor-related histomorphology information at the patch level based on medical prior knowledge; (2) generating representative cluster-level features through histomorphology-driven cluster pooling; and (3) enabling WSI-level classification through histomorphology-driven multi-instance aggregation. With the incorporation of histomorphological information, our framework strengthens the model's ability to capture key and fine-grained pathological patterns, thereby enhancing WSI classification performance. Experimental results demonstrate its effectiveness, achieving high diagnostic accuracy for molecular subtyping and cancer subtyping. The code will be made available at https://github.com/Badgewho/HMDMIL.

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