From RAG to Agentic: Validating Islamic-Medicine Responses with LLM Agents
- URL: http://arxiv.org/abs/2506.15911v2
- Date: Mon, 23 Jun 2025 02:12:38 GMT
- Title: From RAG to Agentic: Validating Islamic-Medicine Responses with LLM Agents
- Abstract summary: Islamic texts like Avicenna's Canon of Medicine and the Prophetic Tibb-e-Nabawi encode a wealth of preventive care, nutrition, and holistic therapies.<n> Existing language-model benchmarks focus narrowly on factual recall or user preference.<n>We propose a unified evaluation pipeline, Tibbe-AG, that aligns 30 carefully curated Prophetic-medicine questions with human-verified remedies.
- Score: 5.391445566482165
- License: http://creativecommons.org/licenses/by/4.0/
- Abstract: Centuries-old Islamic medical texts like Avicenna's Canon of Medicine and the Prophetic Tibb-e-Nabawi encode a wealth of preventive care, nutrition, and holistic therapies, yet remain inaccessible to many and underutilized in modern AI systems. Existing language-model benchmarks focus narrowly on factual recall or user preference, leaving a gap in validating culturally grounded medical guidance at scale. We propose a unified evaluation pipeline, Tibbe-AG, that aligns 30 carefully curated Prophetic-medicine questions with human-verified remedies and compares three LLMs (LLaMA-3, Mistral-7B, Qwen2-7B) under three configurations: direct generation, retrieval-augmented generation, and a scientific self-critique filter. Each answer is then assessed by a secondary LLM serving as an agentic judge, yielding a single 3C3H quality score. Retrieval improves factual accuracy by 13%, while the agentic prompt adds another 10% improvement through deeper mechanistic insight and safety considerations. Our results demonstrate that blending classical Islamic texts with retrieval and self-evaluation enables reliable, culturally sensitive medical question-answering.
Related papers
- PaperDoctor: Evidence-Grounded and Actionable Feedback for Scientific Papers in Progress [130.58520199343707]
PaperDoctor is an agent framework for pre-submission feedback with three key innovations.<n>First, a holistic hierarchical framework evaluates writing, layout, references, code, theory, prior work, and experiments.<n>Second, each finding contains an observation, a pointer to specific evidence such as a sentence, equation, or code line, and a revision suggestion.<n>Third, PaperDoctor selectively rebuilds and reruns experiments based on claim importance and compute budget.
arXiv Detail & Related papers (2026-09-15T11:08:11Z) - Trust but Verify: Mitigating Medical Hallucinations via Post-Hoc Adversarial Auditing and Multi-Agent Feedback Loops [0.07249400282852114]
Large Language Models (LLMs) are increasingly deployed in healthcare settings, yet their tendency to hallucinate poses risks when clinical decisions are involved.<n>This study examine whether LLMs recommend recently banned or withdrawn pharmaceuticals when answering clinical questions.<n>We developed a five-agent "Trust but verify" system using a single LLM backbone.
arXiv Detail & Related papers (2026-06-12T06:21:19Z) - PubMed Reasoner: Dynamic Reasoning-based Retrieval for Evidence-Grounded Biomedical Question Answering [12.717987334814692]
We introduce PubMed Reasoner, a biomedical QA agent composed of three stages.<n>Self-critic query refinement evaluates MeSH terms for coverage, alignment, and redundancy to enhance PubMed queries.<n> reflective retrieval processes articles in batches until sufficient evidence is gathered.<n>Evidence-grounded response generation produces answers with explicit citations.
arXiv Detail & Related papers (2026-03-28T16:41:57Z) - MedArena: Comparing LLMs for Medicine-in-the-Wild Clinician Preferences [50.71326426975699]
We present MedArena, an interactive evaluation platform for medical large language models (LLMs)<n>Given a clinician-provided query, MedArena presents responses from two randomly selected models and asks the user to select the preferred response.<n>Out of 1571 preferences collected across 12 LLMs up to November 1, 2025, Gemini 2.0 Flash Thinking, Gemini 2.5 Pro, and GPT-4o were the top three models by Bradley-Terry rating.
arXiv Detail & Related papers (2026-03-13T22:30:26Z) - A Multi-Agent Framework for Medical AI: Leveraging Fine-Tuned GPT, LLaMA, and DeepSeek R1 for Evidence-Based and Bias-Aware Clinical Query Processing [0.4349324020366305]
Large language models (LLMs) show promise for healthcare question answering, but clinical use is limited by weak verification, insufficient evidence grounding, and unreliable confidence signalling.<n>We propose a multi-agent medical QA framework that combines complementary LLMs with evidence retrieval, uncertainty estimation, and bias checks to improve answer reliability.
arXiv Detail & Related papers (2026-02-15T14:17:27Z) - MedRECT: A Medical Reasoning Benchmark for Error Correction in Clinical Texts [0.0]
Large language models (LLMs) show increasing promise in medical applications, but their ability to detect and correct errors in clinical texts remains under-evaluated.<n>We introduce MedRECT, a cross-lingual benchmark (Japanese/English) that formulates medical error handling as three subtasks.<n>We evaluate 9 contemporary LLMs spanning proprietary, open-weight, and reasoning families.
arXiv Detail & Related papers (2025-11-01T06:19:34Z) - DispatchMAS: Fusing taxonomy and artificial intelligence agents for emergency medical services [49.70819009392778]
Large Language Models (LLMs) and Multi-Agent Systems (MAS) offer opportunities to augment dispatchers.<n>This study aimed to develop and evaluate a taxonomy-grounded, multi-agent system for simulating realistic scenarios.
arXiv Detail & Related papers (2025-10-24T08:01:21Z) - MedTrust-RAG: Evidence Verification and Trust Alignment for Biomedical Question Answering [21.855579328680246]
We propose MedTrust-Guided Iterative RAG, a framework designed to enhance factual consistency and hallucinations in medical QA.<n>First, it enforces citation-aware reasoning by requiring all generated content to be explicitly grounded in retrieved medical documents.<n>Second, it employs an iterative retrieval-verification process, where a verification agent assesses evidence adequacy.
arXiv Detail & Related papers (2025-10-16T07:59:11Z) - MedKGent: A Large Language Model Agent Framework for Constructing Temporally Evolving Medical Knowledge Graph [57.54231831309079]
We introduce MedKGent, a framework for constructing temporally evolving medical Knowledge Graphs.<n>We simulate the emergence of biomedical knowledge via a fine-grained daily time series.<n>The resulting KG contains 156,275 entities and 2,971,384 relational triples.
arXiv Detail & Related papers (2025-08-17T15:14:03Z) - LLMEval-Med: A Real-world Clinical Benchmark for Medical LLMs with Physician Validation [38.02853540388593]
evaluating large language models (LLMs) in medicine is crucial because medical applications require high accuracy with little room for error.<n>We present LLMEval-Med, a new benchmark covering five core medical areas, including 2,996 questions created from real-world electronic health records and expert-designed clinical scenarios.
arXiv Detail & Related papers (2025-06-04T15:43:14Z) - Improving Reliability and Explainability of Medical Question Answering through Atomic Fact Checking in Retrieval-Augmented LLMs [4.003209132872364]
Large language models (LLMs) exhibit extensive medical knowledge but are prone to hallucinations and inaccurate citations.<n>Current methods, such as Retrieval Augmented Generation, partially address these issues by grounding answers in source documents.<n>We introduce a novel atomic fact-checking framework designed to enhance the reliability and explainability of LLMs.
arXiv Detail & Related papers (2025-05-30T17:33:07Z) - AutoMedEval: Harnessing Language Models for Automatic Medical Capability Evaluation [55.2739790399209]
We present AutoMedEval, an open-sourced automatic evaluation model with 13B parameters specifically engineered to measure the question-answering proficiency of medical LLMs.<n>The overarching objective of AutoMedEval is to assess the quality of responses produced by diverse models, aspiring to significantly reduce the dependence on human evaluation.
arXiv Detail & Related papers (2025-05-17T07:44:54Z) - Med-CoDE: Medical Critique based Disagreement Evaluation Framework [72.42301910238861]
The reliability and accuracy of large language models (LLMs) in medical contexts remain critical concerns.<n>Current evaluation methods often lack robustness and fail to provide a comprehensive assessment of LLM performance.<n>We propose Med-CoDE, a specifically designed evaluation framework for medical LLMs to address these challenges.
arXiv Detail & Related papers (2025-04-21T16:51:11Z) - TheBlueScrubs-v1, a comprehensive curated medical dataset derived from the internet [1.4043931310479378]
TheBlueScrubs-v1 is a curated dataset of over 25 billion medical tokens drawn from a broad-scale internet corpus.<n>Each text is assigned three LLM-based quality scores encompassing medical relevance, precision and factual detail, and safety and ethical standards.<n>This Data Descriptor details the dataset's creation and validation, underscoring its potential utility for medical AI research.
arXiv Detail & Related papers (2025-04-01T22:25:19Z) - Quantifying the Reasoning Abilities of LLMs on Real-world Clinical Cases [48.87360916431396]
We introduce MedR-Bench, a benchmarking dataset of 1,453 structured patient cases, annotated with reasoning references.<n>We propose a framework encompassing three critical examination recommendation, diagnostic decision-making, and treatment planning, simulating the entire patient care journey.<n>Using this benchmark, we evaluate five state-of-the-art reasoning LLMs, including DeepSeek-R1, OpenAI-o3-mini, and Gemini-2.0-Flash Thinking, etc.
arXiv Detail & Related papers (2025-03-06T18:35:39Z) - Structured Outputs Enable General-Purpose LLMs to be Medical Experts [50.02627258858336]
Large language models (LLMs) often struggle with open-ended medical questions.<n>We propose a novel approach utilizing structured medical reasoning.<n>Our approach achieves the highest Factuality Score of 85.8, surpassing fine-tuned models.
arXiv Detail & Related papers (2025-03-05T05:24:55Z) - MedHallu: A Comprehensive Benchmark for Detecting Medical Hallucinations in Large Language Models [82.30696225661615]
We introduce MedHallu, the first benchmark specifically designed for medical hallucination detection.<n>We show that state-of-the-art LLMs, including GPT-4o, Llama-3.1, and medically fine-tuned UltraMedical, struggle with this binary hallucination detection task.<n>Using bidirectional entailment clustering, we show that harder-to-detect hallucinations are semantically closer to ground truth.
arXiv Detail & Related papers (2025-02-20T06:33:23Z) - KGARevion: An AI Agent for Knowledge-Intensive Biomedical QA [31.080514888803886]
KGARevion is a knowledge graph-based agent that answers knowledge-intensive questions.<n>It generates relevant triplets by leveraging the latent knowledge embedded in a large language model.<n>It then verifies these triplets against a grounded knowledge graph, filtering out errors and retaining only accurate, contextually relevant information.
arXiv Detail & Related papers (2024-10-07T00:17:37Z) - Challenges of GPT-3-based Conversational Agents for Healthcare [11.517862889784293]
This paper investigates the challenges and risks of using GPT-3-based models for medical question-answering (MedQA)
We provide a procedure for manually designing patient queries to stress-test high-risk limitations of LLMs in MedQA systems.
Our analysis reveals that LLMs fail to respond adequately to these queries, generating erroneous medical information, unsafe recommendations, and content that may be considered offensive.
arXiv Detail & Related papers (2023-08-28T15:12:34Z) - MedAlign: A Clinician-Generated Dataset for Instruction Following with
Electronic Medical Records [60.35217378132709]
Large language models (LLMs) can follow natural language instructions with human-level fluency.
evaluating LLMs on realistic text generation tasks for healthcare remains challenging.
We introduce MedAlign, a benchmark dataset of 983 natural language instructions for EHR data.
arXiv Detail & Related papers (2023-08-27T12:24:39Z)
This list is automatically generated from the titles and abstracts of the papers in this site.
This site does not guarantee the quality of this site (including all information) and is not responsible for any consequences.