NORA: A Nephrology-Oriented Representation Learning Approach Towards Chronic Kidney Disease Classification

• URL: http://arxiv.org/abs/2509.12704v1
• Date: Tue, 16 Sep 2025 05:54:33 GMT
• Title: NORA: A Nephrology-Oriented Representation Learning Approach Towards Chronic Kidney Disease Classification
• Authors: Mohammad Abdul Hafeez Khan, Twisha Bhattacharyya, Omar Khan, Noorah Khan, Alina Aziz Fatima Khan, Mohammed Qutub Khan, Sujoy Ghosh Hajra,
• Abstract summary: Chronic Kidney Disease (CKD) affects millions of people worldwide, yet its early detection remains challenging.<n>We introduce the Nephrology-Oriented Representation leArning (NORA) approach, which combines supervised contrastive learning with a nonlinear Random Forest classifier.<n>Our results demonstrated that NORA improves class separability and overall classification performance, particularly enhancing the F1-score for early-stage CKD.
• Score: 2.785096184515774
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: Chronic Kidney Disease (CKD) affects millions of people worldwide, yet its early detection remains challenging, especially in outpatient settings where laboratory-based renal biomarkers are often unavailable. In this work, we investigate the predictive potential of routinely collected non-renal clinical variables for CKD classification, including sociodemographic factors, comorbid conditions, and urinalysis findings. We introduce the Nephrology-Oriented Representation leArning (NORA) approach, which combines supervised contrastive learning with a nonlinear Random Forest classifier. NORA first derives discriminative patient representations from tabular EHR data, which are then used for downstream CKD classification. We evaluated NORA on a clinic-based EHR dataset from Riverside Nephrology Physicians. Our results demonstrated that NORA improves class separability and overall classification performance, particularly enhancing the F1-score for early-stage CKD. Additionally, we assessed the generalizability of NORA on the UCI CKD dataset, demonstrating its effectiveness for CKD risk stratification across distinct patient cohorts.

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