AI-Assisted Pleural Effusion Volume Estimation from Contrast-Enhanced CT Images

• URL: http://arxiv.org/abs/2510.03856v1
• Date: Sat, 04 Oct 2025 16:06:10 GMT
• Title: AI-Assisted Pleural Effusion Volume Estimation from Contrast-Enhanced CT Images
• Authors: Sanhita Basu, Tomas Fröding, Ali Teymur Kahraman, Dimitris Toumpanakis, Tobias Sjöblom,
• Abstract summary: Pleuralfusions (PE) is a common finding in many different clinical conditions.<n> accurately measuring their volume from CT scans is challenging.<n>We have developed and trained a semi-supervised deep learning framework on contrast-enhanced CT volumes.
• Score: 0.0
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: Background: Pleural Effusions (PE) is a common finding in many different clinical conditions, but accurately measuring their volume from CT scans is challenging. Purpose: To improve PE segmentation and quantification for enhanced clinical management, we have developed and trained a semi-supervised deep learning framework on contrast-enhanced CT volumes. Materials and Methods: This retrospective study collected CT Pulmonary Angiogram (CTPA) data from internal and external datasets. A subset of 100 cases was manually annotated for model training, while the remaining cases were used for testing and validation. A novel semi-supervised deep learning framework, Teacher-Teaching Assistant-Student (TTAS), was developed and used to enable efficient training in non-segmented examinations. Segmentation performance was compared to that of state-of-the-art models. Results: 100 patients (mean age, 72 years, 28 [standard deviation]; 55 men) were included in the study. The TTAS model demonstrated superior segmentation performance compared to state-of-the-art models, achieving a mean Dice score of 0.82 (95% CI, 0.79 - 0.84) versus 0.73 for nnU-Net (p < 0.0001, Student's T test). Additionally, TTAS exhibited a four-fold lower mean Absolute Volume Difference (AbVD) of 6.49 mL (95% CI, 4.80 - 8.20) compared to nnU-Net's AbVD of 23.16 mL (p < 0.0001). Conclusion: The developed TTAS framework offered superior PE segmentation, aiding accurate volume determination from CT scans.

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