Broadly Tunable Quantum Enhanced Raman Microscopy for Advancing Bioimaging

• URL: http://arxiv.org/abs/2511.01430v1
• Date: Mon, 03 Nov 2025 10:29:31 GMT
• Title: Broadly Tunable Quantum Enhanced Raman Microscopy for Advancing Bioimaging
• Authors: Dmitrii Akatev, Yijian Meng, Jonathan Brewer, Maria Chekhova, Ulrik L. Andersen, Mikael Lassen,
• Abstract summary: Raman microscopy is a powerful technique for probing the dynamics of molecular bonds with exceptional sensitivity, resolution, and speed.<n>Here, we demonstrate a quantum-enhanced SRS microscopy platform that circumvents optical shot noise.<n>Our quantum-enhanced Raman microscope achieves an average noise suppression of $3.6mathrmdB$ and a $51%$ enhancement in signal-to-noise ratio (SNR) -- the largest improvement reported to date in quantum-enhanced SRS microscopy of biological samples.
• Score: 0.0
• License: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Abstract: Stimulated Raman scattering (SRS) microscopy has emerged as a powerful technique for probing the spatiotemporal dynamics of molecular bonds with exceptional sensitivity, resolution, and speed. However, classically, its performance remains fundamentally constrained by optical shot noise, which imposes a strict limit on detection sensitivity and speed. Here, we demonstrate a quantum-enhanced SRS microscopy platform that circumvents this barrier by harnessing amplitude-squeezed light. Specifically, we generate a Stokes beam with $5.2~\mathrm{dB}$ of amplitude squeezing using traveling-wave optical parametric amplification in second-order nonlinear waveguides, and combine it with a tunable coherent pump to access vibrational modes spanning from $1000$ to $3100~\mathrm{cm}^{-1}$. Applied to quantum imaging of metabolites in biological tissue (pork muscle), our quantum-enhanced Raman microscope achieves an average noise suppression of $3.6~\mathrm{dB}$ and a $51\%$ enhancement in signal-to-noise ratio (SNR) -- to the best of our knowledge, the largest improvement reported to date in quantum-enhanced SRS microscopy of biological samples.

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