MedFuse: Multiplicative Embedding Fusion For Irregular Clinical Time Series

• URL: http://arxiv.org/abs/2511.09247v1
• Date: Thu, 13 Nov 2025 01:42:39 GMT
• Title: MedFuse: Multiplicative Embedding Fusion For Irregular Clinical Time Series
• Authors: Yi-Hsien Hsieh, Ta-Jung Chien, Chun-Kai Huang, Shao-Hua Sun, Che Lin,
• Abstract summary: We propose MedFuse, a framework for irregular clinical time series based on the MuFuse module.<n>Experiments on three real-world datasets show that MedFuse consistently outperforms state-of-the-art baselines on key predictive tasks.<n>These results establish MedFuse as a generalizable approach for modeling irregular clinical time series.
• Score: 13.933658032225317
• License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
• Abstract: Clinical time series derived from electronic health records (EHRs) are inherently irregular, with asynchronous sampling, missing values, and heterogeneous feature dynamics. While numerical laboratory measurements are highly informative, existing embedding strategies usually combine feature identity and value embeddings through additive operations, which constrains their ability to capture value-dependent feature interactions. We propose MedFuse, a framework for irregular clinical time series centered on the MuFuse (Multiplicative Embedding Fusion) module. MuFuse fuses value and feature embeddings through multiplicative modulation, preserving feature-specific information while modeling higher-order dependencies across features. Experiments on three real-world datasets covering both intensive and chronic care show that MedFuse consistently outperforms state-of-the-art baselines on key predictive tasks. Analysis of the learned representations further demonstrates that multiplicative fusion enhances expressiveness and supports cross-dataset pretraining. These results establish MedFuse as a generalizable approach for modeling irregular clinical time series.

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