QuanvNeXt: An end-to-end quanvolutional neural network for EEG-based detection of major depressive disorder

• URL: http://arxiv.org/abs/2512.09517v1
• Date: Wed, 10 Dec 2025 10:44:47 GMT
• Title: QuanvNeXt: An end-to-end quanvolutional neural network for EEG-based detection of major depressive disorder
• Authors: Nabil Anan Orka, Ehtashamul Haque, Maftahul Jannat, Md Abdul Awal, Mohammad Ali Moni,
• Abstract summary: QuanvNeXt is an end-to-end fully quanvolutional model for EEG-based depression diagnosis.<n>It achieves an average accuracy of 93.1% and an average AUC-ROC of 97.2%, outperforming state-of-the-art baselines.
• Score: 2.819628349300034
• License: http://creativecommons.org/licenses/by-nc-sa/4.0/
• Abstract: This study presents QuanvNeXt, an end-to-end fully quanvolutional model for EEG-based depression diagnosis. QuanvNeXt incorporates a novel Cross Residual block, which reduces feature homogeneity and strengthens cross-feature relationships while retaining parameter efficiency. We evaluated QuanvNeXt on two open-source datasets, where it achieved an average accuracy of 93.1% and an average AUC-ROC of 97.2%, outperforming state-of-the-art baselines such as InceptionTime (91.7% accuracy, 95.9% AUC-ROC). An uncertainty analysis across Gaussian noise levels demonstrated well-calibrated predictions, with ECE scores remaining low (0.0436, Dataset 1) to moderate (0.1159, Dataset 2) even at the highest perturbation (ε = 0.1). Additionally, a post-hoc explainable AI analysis confirmed that QuanvNeXt effectively identifies and learns spectrotemporal patterns that distinguish between healthy controls and major depressive disorder. Overall, QuanvNeXt establishes an efficient and reliable approach for EEG-based depression diagnosis.

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