A Robust Framework for Secure Cardiovascular Risk Prediction: An Architectural Case Study of Differentially Private Federated Learning

• URL: http://arxiv.org/abs/2603.13293v1
• Date: Sat, 28 Feb 2026 09:36:38 GMT
• Title: A Robust Framework for Secure Cardiovascular Risk Prediction: An Architectural Case Study of Differentially Private Federated Learning
• Abstract summary: FedCVR Learning is a privacy-preserving framework applied to heterogeneous clinical networks.<n>We quantify the operational trade-offs of server-side adaptive optimization under utility-prioritized Differential Privacy.<n>Our findings confirm that server-side adaptivity is a structural prerequisite for recovering clinical utility under realistic privacy budgets.
• Score: 0.0
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: Accurate cardiovascular risk prediction is crucial for preventive healthcare; however, the development of robust Artificial Intelligence (AI) models is hindered by the fragmentation of clinical data across institutions due to stringent privacy regulations. This paper presents a comprehensive architectural case study validating the engineering robustness of FedCVR, a privacy-preserving Federated Learning framework applied to heterogeneous clinical networks. Rather than proposing a new theoretical optimizer, this work focuses on a systems engineering analysis to quantify the operational trade-offs of server-side adaptive optimization under utility-prioritized Differential Privacy (DP). By conducting a rigorous stress test in a high-fidelity synthetic environment calibrated against real-world datasets (Framingham, Cleveland), we systematically evaluate the system's resilience to statistical noise. The validation results demonstrate that integrating server-side momentum as a temporal denoiser allows the architecture to achieve a stable F1-score of 0.84 and an Area Under the Curve (AUC) of 0.96, statistically outperforming standard stateless baselines. Our findings confirm that server-side adaptivity is a structural prerequisite for recovering clinical utility under realistic privacy budgets, providing a validated engineering blueprint for secure multi-institutional collaboration.

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