One Size does not Fit All: Heterogeneous Latent Space Alignment for Unsupervised Domain Adaptation

• URL: http://arxiv.org/abs/2606.21415v1
• Date: Fri, 19 Jun 2026 13:33:38 GMT
• Title: One Size does not Fit All: Heterogeneous Latent Space Alignment for Unsupervised Domain Adaptation
• Abstract summary: Domain shift is a major obstacle to the reliable deployment of machine learning models in high-stakes environments such as healthcare.<n>We propose a novel deep learning architecture for Unsupervised Domain Adaptation (UDA), specifically optimized for medical image segmentation.<n>Our framework, ADualVUOT, integrates a dual-encoder Variational Autoencoder (VAE) with Continuous Normalizing Flows (CNFs) to increase modeling flexibility.
• Score: 5.6374247694410995
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: Domain shift remains a major obstacle to the reliable deployment of machine learning models in high-stakes environments such as healthcare. While Domain adaptation aims to mitigate these effects, existing approaches suffer from limited expressiveness of latent representations and a reliance on handcrafted, static augmentations. In this work, we address these limitations by proposing a novel deep learning architecture for Unsupervised Domain Adaptation (UDA), specifically optimized for medical image segmentation. Our framework, ADualVUOT, integrates a dual-encoder Variational Autoencoder (VAE) with Continuous Normalizing Flows (CNFs) to increase modeling flexibility and posterior expressiveness. To achieve domain alignment, we leverage Unbalanced Optimal Transport (UOT) through the Gaussian-Gromov-Wasserstein (GGW) distance, which handles structural and topological discrepancies between domains. Furthermore, we incorporate an adversarial augmentation scheme to synthesize worst-case compositions, thus enhancing model robustness. Extensive experiments on medical imaging benchmarks show significant gains over prior OT-based approaches.

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