NeuroBridge: Bridging Multi-Task MRI Knowledge for Neurodegenerative Disease Diagnosis

• URL: http://arxiv.org/abs/2607.01401v1
• Date: Wed, 01 Jul 2026 19:03:42 GMT
• Title: NeuroBridge: Bridging Multi-Task MRI Knowledge for Neurodegenerative Disease Diagnosis
• Abstract summary: Accurate MRI-based identification of Alzheimer's disease (AD), mild cognitive impairment (MCI), and related dementias remains challenging.<n>We developed NeuroBridge, a clinically guided multi-task framework for neurodegenerative disease diagnosis.
• Score: 6.4094392017896356
• License: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Abstract: INTRODUCTION: Accurate MRI-based identification of Alzheimer's disease (AD), mild cognitive impairment (MCI), and related dementias remains challenging because disease-related structural changes are often subtle and heterogeneous. We developed NeuroBridge, a clinically guided multi-task MRI framework for neurodegenerative disease diagnosis. METHODS: NeuroBridge integrates large-scale self-supervised MRI pretraining with hippocampal segmentation, hippocampal atrophy classification, and reconstruction objectives, followed by gated fusion fine-tuning. Performance was evaluated across ADNI and OASIS cohorts, including cross-cohort transfer, probability-based analysis, and opportunistic screening. RESULTS: NeuroBridge achieved the highest performance across evaluated classification tasks, reaching 88.17% accuracy for AD versus cognitively normal controls in ADNI and 82.78% in OASIS. The largest gains occurred in MCI-related and mixed-diagnosis settings. The framework demonstrated strong cross-cohort generalization, systematic associations between predicted-class probability and accuracy, and the feasibility of probability-based opportunistic screening. DISCUSSION: Clinically guided multi-task representation learning improves neurodegenerative MRI diagnosis beyond conventional single-task approaches. NeuroBridge provides a robust and scalable framework for dementia assessment and MRI-based opportunistic screening.

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