SeekBrain: An Autonomous Multi-Agent System for Accelerating Neuroscience Discovery

• URL: http://arxiv.org/abs/2607.29347v1
• Date: Fri, 31 Jul 2026 12:30:12 GMT
• Title: SeekBrain: An Autonomous Multi-Agent System for Accelerating Neuroscience Discovery
• Abstract summary: SeekBrain is a framework designed to accelerate neuroscience discovery through domain-grounded hierarchical planning and cross-modal data analysis.<n>By coupling this codified expertise with agentic planning and execution engines, the framework scalably generates hypotheses and analytical pipelines on demand.<n>These results establish SeekBrain as a scalable and practical tool for accelerating data-driven discoveries in neuroscience.
• Score: 70.26731349963639
• License: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Abstract: Modern neuroscience relies on integrating multi-scale, multimodal datasets to uncover the neural principles underlying intelligence. However, analytical challenges posed by highly heterogeneous data and fragmented workflows increasingly constrain discoveries. Here we introduce SeekBrain, an autonomous multi-agent framework designed to accelerate neuroscience discovery through domain-grounded hierarchical planning and cross-modal data analysis. SeekBrain dynamically constructs a repertoire of analysis recipes extracted from code-paper pairs. By coupling this codified expertise with agentic planning and execution engines, the framework scalably generates hypotheses and analytical pipelines on demand. Systematic evaluation on the expert-annotated BrainArena benchmark demonstrates that SeekBrain substantially outperforms state-of-the-art agent baselines across various analysis tasks. Crucially, when deployed in real-world research, SeekBrain integrated behavioral, neural, and anatomical data to reveal structured, distributed neural representations of larval zebrafish behavior and a shared axis of regional decoding strength across the brain in a mouse decision-making task. These results establish SeekBrain as a scalable and practical tool for accelerating data-driven discoveries in neuroscience.

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