Subtraction-Based Tumor Segmentation and Lesion-Centered pCR Prediction for the MAMA-MIA Challenge

• URL: http://arxiv.org/abs/2608.29162v1
• Date: Sat, 29 Aug 2026 09:23:45 GMT
• Title: Subtraction-Based Tumor Segmentation and Lesion-Centered pCR Prediction for the MAMA-MIA Challenge
• Abstract summary: We describe the submission of team FME to the MAMA-MIA Challenge.<n>It evaluated primary tumor segmentation and prediction of pathological complete response.<n>FME ranked second in both tasks.
• Score: 0.0
• License: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Abstract: We describe the submission of team FME to the MAMA-MIA Challenge, which evaluated primary tumor segmentation and prediction of pathological complete response (pCR) from pretreatment dynamic contrast-enhanced breast MRI on an external multi-country cohort. For segmentation, we trained a five-fold residual-encoder nnU-Net ensemble using only the first post-contrast minus pre-contrast image, combined with mirroring test-time augmentation and largest-connected-component filtering. For pCR prediction, we ensembled 25 pretrained 3D video classifiers trained on lesion-centred crops from the pre-contrast and first two post-contrast volumes. FME ranked second in both tasks. The segmentation method achieved a combined performance-fairness score of 0.882, with Dice 0.713 and normalized Hausdorff distance 0.099. The pCR method achieved a combined score of 0.664, balanced accuracy of 0.541, and equalized-odds disparity of 0.212. The results indicate that subtraction-based input and ensembling support robust tumor segmentation under cross-site domain shift, whereas pCR prediction from baseline DCE-MRI alone remains limited. For the submission repository, see https://github.com/FraunhoferMEVIS/MAMA-MIA-Challenge-FME

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