Four Ledgers, Not One Score: Responsible Communication of LLM-Judge Calibration in Biomedical ML
- URL: http://arxiv.org/abs/2609.15015v1
- Date: Mon, 14 Sep 2026 04:27:58 GMT
- Title: Four Ledgers, Not One Score: Responsible Communication of LLM-Judge Calibration in Biomedical ML
- Abstract summary: We formalize four distinct ledgers: planted perturbations, independent detector outputs, source-linked human dispositions, and human-added discoveries.<n>This single-workflow forensic case is an existence proof of a failure mode, not an estimate of its prevalence.
- Score: 0.39287497907611874
- License: http://creativecommons.org/licenses/by/4.0/
- Abstract: Synthetic perturbations appear to offer inexpensive calibration data for LLM evaluators in biomedical ML, where expert review is scarce. Yet a planted mutation key is neither a detector output nor automatically human ground truth. We formalize four distinct ledgers: planted perturbations, independent detector outputs, source-linked human dispositions, and human-added discoveries. We then audit the evaluation design, scoring code, read paths, and current human records of a private synthetic Japanese care-handoff workflow. The factory stored 69 planted error cards across 47 targets. Final review covers 22 targets and contains 22 confirmed imported proposals, 9 rejected proposals, and 79 human-added cards; only 3 reviewed targets are double annotated. Passing imported plant keys to a generic detector scorer yields 22/(22+9)=0.710 and 22/(22+79)=0.218. A direct audit identity shows that these values are proposal-confirmation yield and submitted-ledger composition, not judge precision and recall, because no independent detector realization was preserved for the audited proposals in the available records. The audit also finds source-name collisions, row shadowing, forced severity, vacuous ratio defaults, and unsupported zero-support field weights. We contribute a provenance-aware claim audit, a storage contract, and a minimum calibration gate for responsibly communicating biomedical ML capability claims. This single-workflow forensic case is an existence proof of a failure mode, not an estimate of its prevalence: existing human work supports an exploratory audit of synthetic proposals, but not LLM-judge operating characteristics, clinical validity, corpus prevalence, or robust inter-annotator agreement.
Related papers
- IdeaAMBIG: Benchmarking Implementation-Critical Gaps in Research-Idea Specifications [52.570108663867046]
A research idea may be novel, coherent, and scientifically plausible, yet its proposed method may remain insufficiently specified for faithful implementation.<n>We study the codification readiness of implementation-facing research-method specifications, defined by whether they provide sufficient methodological information for a competent implementer or coding agent to construct the intended method without unsupported assumptions.<n>We introduce IdeaAMBIG, a benchmark of 660 evidence-grounded instances: 163 real-world gaps from reports and GitHub issues, and 497 controlled synthetic gaps injected into codification-ready references.
arXiv Detail & Related papers (2026-09-09T17:59:04Z) - When Auditors Fabricate: Batch-Size Degradation and Confident Hallucination in LLM Detection of Planted Document Contamination [0.0]
We construct a contaminated corpus of 150 academic papers spanning supply chain management and medical research.<n>We inject 450 known contaminants of three types: typographical corruption, semantic reversal, and absurd out-of-context insertion.<n>We evaluate Google Gemini 3.0 Pro's ability to recover a 180-contaminant answer-key subset across 60 documents.
arXiv Detail & Related papers (2026-09-09T04:29:45Z) - The Test Oracle Problem in Synthetic LLM-as-Judge Corpora: Disappearance, Distortion and a Validation Protocol [0.0]
Studies of bias in LLM-as-judge systems typically build synthetic corpora by prompting an LLM to generate a hallucinated answer to pair with a factual one, then presenting both to a judge.<n>We report a case in which this generation step silently failed, and use it to argue that the failure mode is structural rather than incidental.<n>A positive control supports this claim directly: an analogous fault injected into a minimal perturbation-based corpus is caught with 100% accuracy by a zero-cost, zero-human gold-to-negative string comparison.
arXiv Detail & Related papers (2026-07-15T11:12:54Z) - Beyond Scalar Scores: Exploring LLM-based Metrics for Clinical Significance Evaluation in Radiology Reports [49.5225801722164]
Existing metrics obscure this requirement by reducing report quality to a medically ungrounded scalar.<n>We study this boundary using ReEvalMed benchmark as testbed and evaluate metric-level clinical significance.
arXiv Detail & Related papers (2026-06-17T08:10:30Z) - Deterministic Integrity Gates for LLM-Assisted Clinical Manuscript Preparation: An Auditable Biomedical Informatics Architecture [0.3823356975862005]
We describe an architecture pairing generation with verification, resting on three principles.<n>This determinism-where-possible split, organized as an integrity-gate taxonomy, is the core contribution.<n> MedSci Skills is an open-source toolkit of 43 skills with a 21-detector deterministic tier, evaluated on three public-dataset pipelines.
arXiv Detail & Related papers (2026-06-08T13:51:04Z) - CARE: A Conformal Safety Layer for Medical Summarization [24.00849890172944]
Large language models (LLMs) are increasingly used for medical summarization.<n>Existing error-detection methods produce or uncalibrated scores, providing no formal control over missed errors.<n>We introduce Conformal Assessment for Risk Evaluation (CARE), a model-agnostic safety layer that uses conformal risk control to overlay omission and hallucination flags onto calibrated summaries.
arXiv Detail & Related papers (2026-06-08T03:10:45Z) - Epistemic Blinding: An Inference-Time Protocol for Auditing Prior Contamination in LLM-Assisted Analysis [0.0]
Epistemic blinding is a simple inference-time protocol that replaces entity identifiers with anonymous codes before prompting, then compares outputs against an unblinded control.<n>In oncology drug target prioritization across four cancer types, blinding changes 16% of top-20 predictions while preserving identical recovery of validated targets.<n>In S&P 500 equity screening, brand-recognition bias reshapes 30-40% of top-20 rankings across five random seeds.
arXiv Detail & Related papers (2026-04-07T16:06:52Z) - A Granular Study of Safety Pretraining under Model Abliteration [64.24346997570275]
We study model abliteration, a lightweight projection technique designed to remove refusal-sensitive directions.<n>We issue 100 prompts with balanced harmful and harmless cases, classify responses as **Refusal** or **Non-Refusal** using multiple judges, and validate judge fidelity.<n>Our study produces a checkpoint-level characterization of which data-centric safety components remain robust under abliteration.
arXiv Detail & Related papers (2025-10-03T07:01:45Z) - Fact-Checking the Output of Large Language Models via Token-Level Uncertainty Quantification [116.77055746066375]
Large language models (LLMs) are notorious for hallucinating, i.e., producing erroneous claims in their output.
We propose a novel fact-checking and hallucination detection pipeline based on token-level uncertainty quantification.
arXiv Detail & Related papers (2024-03-07T17:44:17Z) - "Knowing When You Don't Know": A Multilingual Relevance Assessment Dataset for Robust Retrieval-Augmented Generation [90.09260023184932]
Retrieval-Augmented Generation (RAG) grounds Large Language Model (LLM) output by leveraging external knowledge sources to reduce factual hallucinations.
NoMIRACL is a human-annotated dataset for evaluating LLM robustness in RAG across 18 typologically diverse languages.
We measure relevance assessment using: (i) hallucination rate, measuring model tendency to hallucinate, when the answer is not present in passages in the non-relevant subset, and (ii) error rate, measuring model inaccuracy to recognize relevant passages in the relevant subset.
arXiv Detail & Related papers (2023-12-18T17:18:04Z) - A New Benchmark and Reverse Validation Method for Passage-level
Hallucination Detection [63.56136319976554]
Large Language Models (LLMs) generate hallucinations, which can cause significant damage when deployed for mission-critical tasks.
We propose a self-check approach based on reverse validation to detect factual errors automatically in a zero-resource fashion.
We empirically evaluate our method and existing zero-resource detection methods on two datasets.
arXiv Detail & Related papers (2023-10-10T10:14:59Z)
This list is automatically generated from the titles and abstracts of the papers in this site.
This site does not guarantee the quality of this site (including all information) and is not responsible for any consequences.