Real-time nanodiamond thermometry probing in-vivo thermogenic responses
- URL: http://arxiv.org/abs/2001.02844v2
- Date: Thu, 16 Jan 2020 09:04:14 GMT
- Title: Real-time nanodiamond thermometry probing in-vivo thermogenic responses
- Authors: Masazumi Fujiwara, Simo Sun, Alexander Dohms, Yushi Nishimura, Ken
Suto, Yuka Takezawa, Keisuke Oshimi, Li Zhao, Nikola Sadzak, Yumi Umehara,
Yoshio Teki, Naoki Komatsu, Oliver Benson, Yutaka Shikano, Eriko Kage-Nakadai
- Abstract summary: Light-emitting nanothermometers based on optically accessible electron spins in nanodiamonds (NDs)
We develop a thermometry system that can measure the temperatures of movable NDs inside live adult worms with a precision of $pm 0.22circrm C$.
- Score: 43.669448080580295
- License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
- Abstract: Real-time temperature monitoring inside living organisms provides a direct
measure of their biological activities, such as homeostatic thermoregulation
and energy metabolism. However, it is challenging to reduce the size of
bio-compatible thermometers down to submicrometers despite their potential
applications for the thermal imaging of subtissue structures with single-cell
resolution. Light-emitting nanothermometers that remotely sense temperature via
optical signals exhibit considerable potential in such \textit{in-vivo}
high-spatial-resolution thermometry. Here, using quantum nanothermometers based
on optically accessible electron spins in nanodiamonds (NDs), we demonstrate
\textit{in-vivo} real-time temperature monitoring inside \textit{Caenorhabditis
elegans} (\textit{C. elegans}) worms. We developed a thermometry system that
can measure the temperatures of movable NDs inside live adult worms with a
precision of $\pm 0.22^{\circ}{\rm C}$. Using this system, we determined the
increase in temperature based on the thermogenic responses of the worms during
the chemical stimuli of mitochondrial uncouplers. Our technique demonstrates
sub-micrometer localization of real-time temperature information in living
animals and direct identification of their pharmacological thermogenesis. The
results obtained facilitate the development of a method to probe subcellular
temperature variation inside living organisms and may allow for quantification
of their biological activities based on their energy expenditures.
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