Antifragility Predicts the Robustness and Evolvability of Biological Networks through Multi-class Classification with a Convolutional Neural Network

• URL: http://arxiv.org/abs/2002.01571v2
• Date: Wed, 2 Sep 2020 10:33:00 GMT
• Title: Antifragility Predicts the Robustness and Evolvability of Biological Networks through Multi-class Classification with a Convolutional Neural Network
• Authors: Hyobin Kim, Stalin Mu\~noz, Pamela Osuna, and Carlos Gershenson
• Abstract summary: We develop a method to estimate the robustness and evolvability of biological networks without an explicit comparison of functions. By means of the differences of antifragility between the original and mutated networks, we train a convolutional neural network (CNN) and test it to classify the properties of robustness and evolvability.
• Score: 0.0
• License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/
• Abstract: Robustness and evolvability are essential properties to the evolution of biological networks. To determine if a biological network is robust and/or evolvable, it is required to compare its functions before and after mutations. However, this sometimes takes a high computational cost as the network size grows. Here we develop a predictive method to estimate the robustness and evolvability of biological networks without an explicit comparison of functions. We measure antifragility in Boolean network models of biological systems and use this as the predictor. Antifragility occurs when a system benefits from external perturbations. By means of the differences of antifragility between the original and mutated biological networks, we train a convolutional neural network (CNN) and test it to classify the properties of robustness and evolvability. We found that our CNN model successfully classified the properties. Thus, we conclude that our antifragility measure can be used as a predictor of the robustness and evolvability of biological networks.

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