Whole MILC: generalizing learned dynamics across tasks, datasets, and populations

• URL: http://arxiv.org/abs/2007.16041v2
• Date: Fri, 18 Jun 2021 20:12:38 GMT
• Title: Whole MILC: generalizing learned dynamics across tasks, datasets, and populations
• Authors: Usman Mahmood, Md Mahfuzur Rahman, Alex Fedorov, Noah Lewis, Zening Fu, Vince D. Calhoun, Sergey M. Plis
• Abstract summary: Theory of disorder-specific dynamics crucial for early diagnosis and understanding disorder mechanism. In this paper we present a novel supervised training model which reinforces whole mutual sequence information local to context. We test our model on three different disorders (i) Schizophrenia (ii) and (iii) Alzheimers and four different studies.
• Score: 14.99255412075299
• License: http://creativecommons.org/licenses/by/4.0/
• Abstract: Behavioral changes are the earliest signs of a mental disorder, but arguably, the dynamics of brain function gets affected even earlier. Subsequently, spatio-temporal structure of disorder-specific dynamics is crucial for early diagnosis and understanding the disorder mechanism. A common way of learning discriminatory features relies on training a classifier and evaluating feature importance. Classical classifiers, based on handcrafted features are quite powerful, but suffer the curse of dimensionality when applied to large input dimensions of spatio-temporal data. Deep learning algorithms could handle the problem and a model introspection could highlight discriminatory spatio-temporal regions but need way more samples to train. In this paper we present a novel self supervised training schema which reinforces whole sequence mutual information local to context (whole MILC). We pre-train the whole MILC model on unlabeled and unrelated healthy control data. We test our model on three different disorders (i) Schizophrenia (ii) Autism and (iii) Alzheimers and four different studies. Our algorithm outperforms existing self-supervised pre-training methods and provides competitive classification results to classical machine learning algorithms. Importantly, whole MILC enables attribution of subject diagnosis to specific spatio-temporal regions in the fMRI signal.

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